Literature DB >> 2056005

Liquid chromatographic determination of the enantiomers of ibuprofen in plasma using a chiral AGP column.

K J Pettersson1, A Olsson.   

Abstract

A reversed-phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen. The enantiomers and the internal standard 4-pentylphenylacetic acid are extracted from plasma, separated and quantified on a Chiral-AGP column using ultraviolet detection. The simplicity, sensitivity and precision of the method makes it convenient for use in pharmacokinetic studies.

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Year:  1991        PMID： 2056005     DOI： 10.1016/0378-4347(91)80050-m

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

1.  Effects of the antifungals voriconazole and fluconazole on the pharmacokinetics of s-(+)- and R-(-)-Ibuprofen.

Authors:  Ville-Veikko Hynninen; Klaus T Olkkola; Kari Leino; Stefan Lundgren; Pertti J Neuvonen; Anders Rane; Mika Valtonen; Hanna Vyyryläinen; Kari Laine
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

Review 2.  Clinical pharmacokinetics of ibuprofen. The first 30 years.

Authors:  N M Davies
Journal:  Clin Pharmacokinet       Date:  1998-02       Impact factor: 6.447

3.  Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen.

Authors:  Aleksi Tornio; Mikko Niemi; Pertti J Neuvonen; Janne T Backman
Journal:  Eur J Clin Pharmacol       Date:  2007-02-27       Impact factor: 2.953

4.  Comparative bioavailability study of codeine and ibuprofen after administration of the two products alone or in association to 24 healthy volunteers.

Authors:  J P Laneury; P Duchene; P Hirt; A Delarue; S Gleizes; G Houin; P Molinier
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1998 Apr-Jun       Impact factor: 2.441
  4 in total

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