Literature DB >> 2055961

Isolation and characterisation of clones from the Caco-2 cell line displaying increased taurocholic acid transport.

S Woodcook1, I Williamson, I Hassan, M Mackay.   

Abstract

The Caco-2 cell line has been cloned by the limiting dilution technique. Clones and reclones have been tested for growth characteristics, transepithelial electrical resistance, ability to transport taurocholic acid specifically and morphological homogeneity. Although clones have similar growth patterns to the parental population they display a variety of electrophysiological, biochemical and morphological characteristics. One clone, clone 40, has been characterised in detail and shown to transport significantly higher amounts of taurocholic acid. Moreover, this clone displays morphological homogeneity and is stable with respect to this parameter over an extended time period.

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Year:  1991        PMID： 2055961     DOI： 10.1242/jcs.98.3.323

Source DB:  PubMed          Journal:  J Cell Sci        ISSN： 0021-9533            Impact factor:   5.285


  9 in total

1.  Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages.

Authors:  H Yu; T J Cook; P J Sinko
Journal:  Pharm Res       Date:  1997-06       Impact factor: 4.200

Review 2.  The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications.

Authors:  V Meunier; M Bourrié; Y Berger; G Fabre
Journal:  Cell Biol Toxicol       Date:  1995-08       Impact factor: 6.691

Review 3.  Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.

Authors:  Vanessa Liévin-Le Moal; Alain L Servin
Journal:  Microbiol Mol Biol Rev       Date:  2013-09       Impact factor: 11.056

4.  Transepithelial transport and metabolism of thyrotropin-releasing hormone (TRH) in monolayers of a human intestinal cell line (Caco-2): evidence for an active transport component?

Authors:  E Walter; T Kissel
Journal:  Pharm Res       Date:  1994-11       Impact factor: 4.200

5.  Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line.

Authors:  M C Grès; B Julian; M Bourrié; V Meunier; C Roques; M Berger; X Boulenc; Y Berger; G Fabre
Journal:  Pharm Res       Date:  1998-05       Impact factor: 4.200

6.  Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments.

Authors:  P Artursson; A L Ungell; J E Löfroth
Journal:  Pharm Res       Date:  1993-08       Impact factor: 4.200

7.  The post-synthetic sorting of endogenous membrane proteins examined by the simultaneous purification of apical and basolateral plasma membrane fractions from Caco-2 cells.

Authors:  J A Ellis; M R Jackman; J P Luzio
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

Review 8.  Human small intestinal organotypic culture model for drug permeation, inflammation, and toxicity assays.

Authors:  Jan Markus; Tim Landry; Zachary Stevens; Hailey Scott; Pierre Llanos; Michelle Debatis; Alexander Armento; Mitchell Klausner; Seyoum Ayehunie
Journal:  In Vitro Cell Dev Biol Anim       Date:  2020-11-25       Impact factor: 2.416

Review 9.  Toroviruses of animals and humans: a review.

Authors:  M Koopmans; M C Horzinek
Journal:  Adv Virus Res       Date:  1994       Impact factor: 9.937
  9 in total

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