OBJECTIVE: To evaluate the impact of inappropriate antibiotic use on inpatients' cost during hospitalization. METHODS: 1 000 cases with antibiotic treatment were extracted from 10 hospitals of 5 provinces in China in 2005. We created multivariate linear regression model for hospital cost and Logistic regression model for evaluation of rationality in antibiotic use. RESULTS: We collected 946 valid cases. Rate of inappropriate antibiotic use was 58.4%. Costs of inpatients with inappropriate antibiotic use was 1.55 times of the ones with appropriate use (P<0.001). Risk factors included antibiotic prophylaxis (OR=2.929), medication for surgery (OR=2.44), long hospital stay (OR=1.021 for every prolonged day) and regional factors. Protection factor was in tertiary hospital (OR=0.510). CONCLUSION: Inappropriate antibiotic use could add 55% unnecessary cost on inpatients. Efforts to control misuse of antibiotics such as regulating antibiotic prophylaxis and medication for surgery, and decreasing length of stay should be pursued.
OBJECTIVE: To evaluate the impact of inappropriate antibiotic use on inpatients' cost during hospitalization. METHODS: 1 000 cases with antibiotic treatment were extracted from 10 hospitals of 5 provinces in China in 2005. We created multivariate linear regression model for hospital cost and Logistic regression model for evaluation of rationality in antibiotic use. RESULTS: We collected 946 valid cases. Rate of inappropriate antibiotic use was 58.4%. Costs of inpatients with inappropriate antibiotic use was 1.55 times of the ones with appropriate use (P<0.001). Risk factors included antibiotic prophylaxis (OR=2.929), medication for surgery (OR=2.44), long hospital stay (OR=1.021 for every prolonged day) and regional factors. Protection factor was in tertiary hospital (OR=0.510). CONCLUSION: Inappropriate antibiotic use could add 55% unnecessary cost on inpatients. Efforts to control misuse of antibiotics such as regulating antibiotic prophylaxis and medication for surgery, and decreasing length of stay should be pursued.
Authors: Asok Kurup; Kui-Hin Liau; Jianan Ren; Min-Chi Lu; Narciso S Navarro; Muhammad Waris Farooka; Nurhayat Usman; Raul V Destura; Boonchoo Sirichindakul; Terapong Tantawichien; Christopher K C Lee; Joseph S Solomkin Journal: Ann Med Surg (Lond) Date: 2014-08-07