| Literature DB >> 20558927 |
Soo Ryang Kim1, Susumu Imoto, Masatoshi Kudo, Taisuke Nakajima, Kenji Ando, Keiji Mita, Katsumi Fukuda, Hyun Soo Hong, Yeong Ho Lee, Keiichi Nakashima, Ikuo Shoji, Motoko Nagano-Fujii, Hak Hotta, Yoshitake Hayashi.
Abstract
We describe a 72-year-old woman with chronic hepatitis C and autoimmune thrombocytopenic purpura (AITP) during pegylated interferon (PEG-IFN) alpha. Immunoglobulin G and antinuclear antibody were 2,113 mg/dL and 1,280 at the start, respectively. A liver biopsy negated autoimmune hepatitis. After a 48-week combination therapy with ribavirin, PEG-IFN alpha-2a was administered. At the 30th month, the platelet count was decreased to 1.1 x 10(4)/microL. Bone marrow biopsy disclosed normocellular marrow compatible with AITP. The platelet-associated IgG (PAIgG) titer rose to 500 ng/10(7) cells. Corticosteroid therapy was successful, and the platelet count and PAIgG titer reverted to 6.4 x 10(4)/microL and 57.3 ng/10(7) cells, respectively.Entities:
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Year: 2010 PMID： 20558927 DOI： 10.2169/internalmedicine.49.3413
Source DB: PubMed Journal: Intern Med ISSN： 0918-2918 Impact factor: 1.271