AIM OF THE STUDY: This study was aimed to evaluate the antiulcer activity of the whole plants of Hedyotis puberula (G. Don) R. Br. ex Arn. MATERIALS AND METHODS: Gastroprotective potential of the Hedyotis puberula methanol extract (200 and 400mg/kg body weight) was studied on indomethacin (IND), ethanol and pyloric ligation (PL)-induced gastric ulcer models in rats. RESULTS: The treatment with Hedyotis puberula extract at 400mg/kg p.o. protected the rats against the ulceration which was comparable to the reference drug omeprazole. Pretreatment with extract protected rats from gastric lesion development by way of increased pH and decreased volume, acidity and pepsin content of gastric secretion. Furthermore, total carbohydrate: protein ratio of the gastric juice were noticeably increased in pretreated rats. CONCLUSION: Results of our study showed that Hedyotis puberula possess significant gastroprotective activity and validate the folklore claim. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
AIM OF THE STUDY: This study was aimed to evaluate the antiulcer activity of the whole plants of Hedyotis puberula (G. Don) R. Br. ex Arn. MATERIALS AND METHODS: Gastroprotective potential of the Hedyotis puberula methanol extract (200 and 400mg/kg body weight) was studied on indomethacin (IND), ethanol and pyloric ligation (PL)-induced gastric ulcer models in rats. RESULTS: The treatment with Hedyotis puberula extract at 400mg/kg p.o. protected the rats against the ulceration which was comparable to the reference drug omeprazole. Pretreatment with extract protected rats from gastric lesion development by way of increased pH and decreased volume, acidity and pepsin content of gastric secretion. Furthermore, total carbohydrate: protein ratio of the gastric juice were noticeably increased in pretreated rats. CONCLUSION: Results of our study showed that Hedyotis puberula possess significant gastroprotective activity and validate the folklore claim. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Giovanni Benelli; Filippo Maggi; Roman Pavela; Kadarkarai Murugan; Marimuthu Govindarajan; Baskaralingam Vaseeharan; Riccardo Petrelli; Loredana Cappellacci; Suresh Kumar; Anders Hofer; Mohammad Reza Youssefi; Abdullah A Alarfaj; Jiang-Shiou Hwang; Akon Higuchi Journal: Environ Sci Pollut Res Int Date: 2017-07-28 Impact factor: 4.223