Literature DB >> 20558248

Kinetics of maternal antibodies against rubella and varicella in infants.

E Leuridan1, N Hens, V Hutse, M Aerts, P Van Damme.   

Abstract

Kinetics of maternal rubella and varicella antibodies in 213 mother-infant pairs are described in a longitudinal study in Belgium. Blood samples are taken at 7 time points (week 36 of pregnancy, birth (cord), 1, 3, 6, 9, and 12 months), and analyzed for anti-rubella IgG and anti-varicella IgG by enzyme linked immunosorbent assay (ELISA). A generalized exponential model is used to analyse maternal antibody decay in infants. Model based, the mean duration of passive immunity is 2.1 months for rubella and 2.4 months for varicella. Infants are susceptible at young age for rubella, a disease with high vaccination coverage, as well as for varicella, an endemic disease in Western Europe.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20558248     DOI： 10.1016/j.vaccine.2010.06.004

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  23 in total

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