| Literature DB >> 20558146 |
Roxanne Sterniczuk1, Michael C Antle, Frank M Laferla, Richard H Dyck.
Abstract
Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that differ from those observed in normal aging. Transgenic models of AD are a promising tool in understanding the underlying mechanisms and cause of disease. The triple-transgenic mouse model of AD (3xTg-AD) is the only model to exhibit both Abeta and tau pathology that is characteristic of the human form. The present study characterized the performance of 3xTg-AD mice on several tasks measuring behavioral and cognitive ability. Aged 3xTg-AD females exhibited a higher level of fear and anxiety demonstrated by increased restlessness, startle responses, and freezing behaviors. No differences were observed in muscle strength and visuo-motor coordination. Understanding the behavioral manifestations that occur in this model of AD may aid in the early diagnosis and appropriate treatment of AD symptomology. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20558146 DOI： 10.1016/j.brainres.2010.06.011
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252