Literature DB >> 2055655

MICs of ciprofloxacin and trimethoprim for Escherichia coli: influence of pH, inoculum size and various body fluids.

J Aagaard1, T Gasser, P Rhodes, P O Madsen.   

Abstract

The influence of pH, inoculum size, human urine and prostatic extract on the MICs of ciprofloxacin and trimethoprim for Escherichia coli was investigated. There was no influence by the bacterial inoculum size within wide ranges on either drug. An increase in pH had a variable influence on the MICs of trimethoprim for E. coli but lowered those of ciprofloxacin considerably. Human prostatic extract increased the trimethoprim MIC for E. coli but lowered those of ciprofloxacin as compared to Mueller Hinton broth. Human urine increased the MICs of both drugs for E. coli.

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Year:  1991        PMID： 2055655     DOI： 10.1007/bf01643691

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  4 in total

1.  Chronic bacterial prostatitis and the diffusion of drugs into prostatic fluid.

Authors:  T A Stamey; E M Meares; D G Winningham
Journal:  J Urol       Date:  1970-02       Impact factor: 7.450

2.  The pH of prostatic fluid: a reappraisal and therapeutic implications.

Authors:  W R Fair; J J Cordonnier
Journal:  J Urol       Date:  1978-12       Impact factor: 7.450

3.  Effects of changes in pH, medium, and inoculum size on the in vitro activity of amifloxacin against urinary isolates of Staphylococcus saprophyticus and Escherichia coli.

Authors:  A Iravani; G S Welty; B R Newton; G A Richard
Journal:  Antimicrob Agents Chemother       Date:  1985-04       Impact factor: 5.191

4.  In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim.

Authors:  N X Chin; H C Neu
Journal:  Antimicrob Agents Chemother       Date:  1983-11       Impact factor: 5.191
  4 in total
  9 in total

Review 1.  Protein binding of antimicrobials: methods for quantification and for investigation of its impact on bacterial killing.

Authors:  Jürgen Beer; Claudia Christina Wagner; Markus Zeitlinger
Journal:  AAPS J       Date:  2009-01-01       Impact factor: 4.009

2.  Influences of urinary pH on ciprofloxacin pharmacokinetics in humans and antimicrobial activity in vitro versus those of sparfloxacin.

Authors:  M Kamberi; K Tsutsumi; T Kotegawa; K Kawano; K Nakamura; Y Niki; S Nakano
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

3.  Comparative in vitro activities of the novel antibacterial finafloxacin against selected Gram-positive and Gram-negative bacteria tested in Mueller-Hinton broth and synthetic urine.

Authors:  Axel Dalhoff; Will Stubbings; Sabine Schubert
Journal:  Antimicrob Agents Chemother       Date:  2011-01-18       Impact factor: 5.191

4.  Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.

Authors:  Jolanta Krucinska; Michael N Lombardo; Heidi Erlandsen; Alexavier Estrada; Debjani Si; Kishore Viswanathan; Dennis L Wright
Journal:  Commun Biol       Date:  2022-05-13

5.  Urinary concentrations and antibacterial activities of nitroxoline at 250 milligrams versus trimethoprim at 200 milligrams against uropathogens in healthy volunteers.

Authors:  Florian M E Wagenlehner; Fabian Münch; Adrian Pilatz; Birte Bärmann; Wolfgang Weidner; Christine M Wagenlehner; Marion Straubinger; Holger Blenk; Wolfgang Pfister; Michael Kresken; Kurt G Naber
Journal:  Antimicrob Agents Chemother       Date:  2013-11-11       Impact factor: 5.191

6.  Urinary Tract Physiological Conditions Promote Ciprofloxacin Resistance in Low-Level-Quinolone-Resistant Escherichia coli.

Authors:  Guillermo Martín-Gutiérrez; Jerónimo Rodríguez-Beltrán; José Manuel Rodríguez-Martínez; Coloma Costas; Javier Aznar; Álvaro Pascual; Jesús Blázquez
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

7.  A population genomics approach to exploiting the accessory 'resistome' of Escherichia coli.

Authors:  Robert J Goldstone; David G E Smith
Journal:  Microb Genom       Date:  2017-04-06

8.  Bacterial interspecies interactions modulate pH-mediated antibiotic tolerance.

Authors:  Andrés Aranda-Díaz; Benjamin Obadia; Ren Dodge; Tani Thomsen; Zachary F Hallberg; Zehra Tüzün Güvener; William B Ludington; Kerwyn Casey Huang
Journal:  Elife       Date:  2020-01-29       Impact factor: 8.140

9.  pH plays a role in the mode of action of trimethoprim on Escherichia coli.

Authors:  Haitham AlRabiah; J William Allwood; Elon Correa; Yun Xu; Royston Goodacre
Journal:  PLoS One       Date:  2018-07-13       Impact factor: 3.240
  9 in total

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