Literature DB >> 20556353

The glucagon-producing alpha cell: an electrophysiologically exceptional cell.

M Braun1, P Rorsman.   

Abstract

Activation of potassium channels normally serves to reduce cellular activity but recent data indicate that the glucagon-secreting alpha cells are different in this respect and that inhibition of voltage-gated potassium channels results in a paradoxical inhibition of glucagon secretion. Here we discuss these findings and attempt to provide a model for the regulation of glucagon secretion that incorporates these observations.

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Year:  2010        PMID： 20556353     DOI： 10.1007/s00125-010-1823-8

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  19 in total

1.  The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.

Authors:  H Heimberg; A De Vos; K Moens; E Quartier; L Bouwens; D Pipeleers; E Van Schaftingen; O Madsen; F Schuit
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

2.  Modifications of A-current kinetics in mammalian central neurones induced by extracellular zinc.

Authors:  R Bardoni; O Belluzzi
Journal:  J Physiol       Date:  1994-09-15       Impact factor: 5.182

3.  ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

Authors:  T Miki; B Liss; K Minami; T Shiuchi; A Saraya; Y Kashima; M Horiuchi; F Ashcroft; Y Minokoshi; J Roeper; S Seino
Journal:  Nat Neurosci       Date:  2001-05       Impact factor: 24.884

4.  Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets.

Authors:  Sylvain J Le Marchand; David W Piston
Journal:  J Biol Chem       Date:  2010-03-15       Impact factor: 5.157

5.  Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels.

Authors:  S O Göpel; T Kanno; S Barg; X G Weng; J Gromada; P Rorsman
Journal:  J Physiol       Date:  2000-11-01       Impact factor: 5.182

6.  Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.

Authors:  S Barg; J Galvanovskis; S O Göpel; P Rorsman; L Eliasson
Journal:  Diabetes       Date:  2000-09       Impact factor: 9.461

Review 7.  Insulin granule dynamics in pancreatic beta cells.

Authors:  P Rorsman; E Renström
Journal:  Diabetologia       Date:  2003-07-17       Impact factor: 10.122

8.  Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels.

Authors:  J Gromada; K Bokvist; W G Ding; S Barg; K Buschard; E Renström; P Rorsman
Journal:  J Gen Physiol       Date:  1997-09       Impact factor: 4.086

9.  Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

Authors:  Michael B Hoppa; Stephan Collins; Reshma Ramracheya; Leanne Hodson; Stefan Amisten; Quan Zhang; Paul Johnson; Frances M Ashcroft; Patrik Rorsman
Journal:  Cell Metab       Date:  2009-12       Impact factor: 27.287

10.  A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

Authors:  Patrick E MacDonald; Yang Zhang De Marinis; Reshma Ramracheya; Albert Salehi; Xiaosong Ma; Paul R V Johnson; Roger Cox; Lena Eliasson; Patrik Rorsman
Journal:  PLoS Biol       Date:  2007-06       Impact factor: 8.029
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  6 in total

1.  Simultaneous capillary electrophoresis competitive immunoassay for insulin, glucagon, and islet amyloid polypeptide secretion from mouse islets of Langerhans.

Authors:  Christelle Guillo; Tuan M Truong; Michael G Roper
Journal:  J Chromatogr A       Date:  2011-05-13       Impact factor: 4.759

Review 2.  The regulation of pre- and post-maturational plasticity of mammalian islet cell mass.

Authors:  Teresa Mezza; Rohit N Kulkarni
Journal:  Diabetologia       Date:  2014-05-14       Impact factor: 10.122

Review 3.  ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

Authors:  Patrik Rorsman; Reshma Ramracheya; Nils J G Rorsman; Quan Zhang
Journal:  Diabetologia       Date:  2014-06-07       Impact factor: 10.122

4.  UCP2 regulates the glucagon response to fasting and starvation.

Authors:  Emma M Allister; Christine A Robson-Doucette; Kacey J Prentice; Alexandre B Hardy; Sobia Sultan; Herbert Y Gaisano; Dong Kong; Patrick Gilon; Pedro L Herrera; Bradford B Lowell; Michael B Wheeler
Journal:  Diabetes       Date:  2013-02-22       Impact factor: 9.461

5.  Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia.

Authors:  Louise Hyltén-Cavallius; Eva W Iepsen; Nicolai J Wewer Albrechtsen; Mathilde Svendstrup; Anniek F Lubberding; Bolette Hartmann; Thomas Jespersen; Allan Linneberg; Michael Christiansen; Henrik Vestergaard; Oluf Pedersen; Jens J Holst; Jørgen K Kanters; Torben Hansen; Signe S Torekov
Journal:  Circulation       Date:  2017-02-24       Impact factor: 29.690

Review 6.  'Resistance is futile?' - paradoxical inhibitory effects of KATP channel closure in glucagon-secreting α-cells.

Authors:  Quan Zhang; Haiqiang Dou; Patrik Rorsman
Journal:  J Physiol       Date:  2020-08-07       Impact factor: 6.228
  6 in total

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