Literature DB >> 20556304

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.

Sinchun Lim1, Brett M Paterson, Michelle T Fodero-Tavoletti, Graeme J O'Keefe, Roberto Cappai, Kevin J Barnham, Victor L Villemagne, Paul S Donnelly.   

Abstract

A bis(thiosemicarbazonato)copper(ii) complex with an appended stilbene functional group binds to amyloid-beta plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography.

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Year:  2010        PMID： 20556304     DOI： 10.1039/c0cc01175d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates.

Authors:  Steven H Liang; Jason P Holland; Nickeisha A Stephenson; Alina Kassenbrock; Benjamin H Rotstein; Cory P Daignault; Rebecca Lewis; Lee Collier; Jacob M Hooker; Neil Vasdev
Journal:  ACS Chem Neurosci       Date:  2015-03-24       Impact factor: 4.418

2.  Gallium-68 Complexes Conjugated to Pittsburgh Compound B: Radiolabeling and Biological Evaluation.

Authors:  Damien Cressier; Martine Dhilly; Thang T Cao Pham; Fabien Fillesoye; Fabienne Gourand; Auriane Maïza; André F Martins; Jean-François Morfin; Carlos F G C Geraldes; Éva Tóth; Louisa Barré
Journal:  Mol Imaging Biol       Date:  2016-06       Impact factor: 3.488

3.  Evaluation of 64Cu-Based Radiopharmaceuticals that Target Aβ Peptide Aggregates as Diagnostic Tools for Alzheimer's Disease.

Authors:  Nilantha Bandara; Anuj K Sharma; Stephanie Krieger; Jason W Schultz; Byung Hee Han; Buck E Rogers; Liviu M Mirica
Journal:  J Am Chem Soc       Date:  2017-08-29       Impact factor: 15.419

Review 4.  Metals in Imaging of Alzheimer's Disease.

Authors:  Olga Krasnovskaya; Daniil Spector; Alexander Zlobin; Kirill Pavlov; Peter Gorelkin; Alexander Erofeev; Elena Beloglazkina; Alexander Majouga
Journal:  Int J Mol Sci       Date:  2020-12-02       Impact factor: 5.923

Review 5.  Copper Coordination Compounds as Biologically Active Agents.

Authors:  Olga Krasnovskaya; Alexey Naumov; Dmitry Guk; Peter Gorelkin; Alexander Erofeev; Elena Beloglazkina; Alexander Majouga
Journal:  Int J Mol Sci       Date:  2020-05-31       Impact factor: 5.923

Review 6.  The essential elements of Alzheimer's disease.

Authors:  Peng Lei; Scott Ayton; Ashley I Bush
Journal:  J Biol Chem       Date:  2020-11-27       Impact factor: 5.157
  6 in total

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