CONTEXT: There is limited information on the association between sex hormones and bone loss in older men. OBJECTIVE: Our objective was to determine the longitudinal association between sex steroid hormones and bone mineral density (BMD). DESIGN AND SETTING: We conducted a prospective study of 5995 men aged at least 65 yr old at six U.S. clinical centers. PARTICIPANTS: Sex steroid hormones were measured in a random sample of 1602 men. After exclusions, 1238 men were included in cross-sectional analyses and 969 in longitudinal analyses. Baseline sex hormones were measured using liquid chromatography-mass spectrometry. Bioavailable (Bio) estradiol (BioE2) and testosterone (BioT) were calculated from mass action equations. SHBG was measured using chemiluminescent substrate. MAIN OUTCOME MEASURES: BMD of the total hip, measured at baseline and once or twice afterward over 4.6 yr of follow-up, was evaluated. RESULTS: The annualized percent change in hip BMD increased with decreasing BioE2 (P trend = 0.03). Men with the lowest BioE2 (<39.7 pmol/liter) compared with the highest BioE2 (> or =66.0 pmol/liter) experienced 38% faster rate of BMD loss (P < 0.05). There was no association between BioT and hip BMD loss. Men with lowest BioE2, lowest BioT, and highest SHBG experienced a 3-fold faster rate of BMD loss compared with men with higher levels (P = 0.02). A threshold effect of SHBG was observed; the rate of hip BMD loss increased in men with SHBG of 49-60 nM. CONCLUSIONS: Low BioE2 and high SHBG levels were associated with lower BMD and faster hip BMD loss. The combination of low BioE2, low BioT, and high SHBG was associated with significantly faster rates of BMD loss.
CONTEXT: There is limited information on the association between sex hormones and bone loss in older men. OBJECTIVE: Our objective was to determine the longitudinal association between sex steroid hormones and bone mineral density (BMD). DESIGN AND SETTING: We conducted a prospective study of 5995 men aged at least 65 yr old at six U.S. clinical centers. PARTICIPANTS: Sex steroid hormones were measured in a random sample of 1602 men. After exclusions, 1238 men were included in cross-sectional analyses and 969 in longitudinal analyses. Baseline sex hormones were measured using liquid chromatography-mass spectrometry. Bioavailable (Bio) estradiol (BioE2) and testosterone (BioT) were calculated from mass action equations. SHBG was measured using chemiluminescent substrate. MAIN OUTCOME MEASURES: BMD of the total hip, measured at baseline and once or twice afterward over 4.6 yr of follow-up, was evaluated. RESULTS: The annualized percent change in hip BMD increased with decreasing BioE2 (P trend = 0.03). Men with the lowest BioE2 (<39.7 pmol/liter) compared with the highest BioE2 (> or =66.0 pmol/liter) experienced 38% faster rate of BMD loss (P < 0.05). There was no association between BioT and hip BMD loss. Men with lowest BioE2, lowest BioT, and highest SHBG experienced a 3-fold faster rate of BMD loss compared with men with higher levels (P = 0.02). A threshold effect of SHBG was observed; the rate of hip BMD loss increased in men with SHBG of 49-60 nM. CONCLUSIONS: Low BioE2 and high SHBG levels were associated with lower BMD and faster hip BMD loss. The combination of low BioE2, low BioT, and high SHBG was associated with significantly faster rates of BMD loss.
Authors: Manthos G Giannoulis; Finbarr C Martin; K Sreekumaran Nair; A Margot Umpleby; Peter Sonksen Journal: Endocr Rev Date: 2012-03-20 Impact factor: 19.871
Authors: Elizabeth Barrett-Connor; Gail A Laughlin; Hong Li; Carrie M Nielson; P Ying Wang; Tien T Dam; Jane A Cauley; Kristine E Ensrud; Marcia L Stefanick; Edith Lau; Andrew R Hoffman; Eric S Orwoll Journal: J Bone Miner Res Date: 2012-11 Impact factor: 6.741
Authors: Gina N Woods; Mei-Hua Huang; Peggy M Cawthon; Gail A Laughlin; John T Schousboe; Corinne McDaniels-Davidson; Jane A Cauley; Eric Orwoll; Elizabeth Barrett-Connor; Deborah M Kado Journal: J Bone Miner Res Date: 2016-11-03 Impact factor: 6.741
Authors: Carrie M Nielson; Jack Wiedrick; Jian Shen; Jon Jacobs; Erin S Baker; Aaron Baraff; Paul Piehowski; Christine G Lee; Arie Baratt; Vladislav Petyuk; Shannon McWeeney; Jeong Youn Lim; Douglas C Bauer; Nancy E Lane; Peggy M Cawthon; Richard D Smith; Jodi Lapidus; Eric S Orwoll Journal: J Bone Miner Res Date: 2017-04-06 Impact factor: 6.741
Authors: Jane A Cauley; Andrew J Burghardt; Stephanie L Harrison; Peggy M Cawthon; Ann V Schwartz; Elizabeth Barrett Connor; Kristine E Ensrud; Lisa Langsetmo; Sharmila Majumdar; Eric Orwoll Journal: J Bone Miner Res Date: 2018-06-12 Impact factor: 6.741
Authors: Eric S Orwoll; Jodi Lapidus; Patty Y Wang; Liesbeth Vandenput; Andrew Hoffman; Howard A Fink; Gail A Laughlin; Maria Nethander; Östen Ljunggren; Andreas Kindmark; Mattias Lorentzon; Magnus K Karlsson; Dan Mellström; Anthony Kwok; Sundeep Khosla; Timothy Kwok; Claes Ohlsson Journal: J Bone Miner Res Date: 2016-11-14 Impact factor: 6.741