Tinuade A Ogunlesi1, Olusoga B Ogunfowora. 1. Department of Paediatrics, Olabisi Onabanjo University Teaching Hospital, Sagamu 121001NG, Nigeria. tinuade_ogunlesi@yahoo.co.uk
Abstract
OBJECTIVE: To determine predictors of acute bilirubin encephalopathy (ABE) among term infants presenting with moderate-to-severe hyperbilirubinaemia. METHODS: Babies with total serum bilirubin >15 mg/dl at the point of admission were studied in a Nigerian tertiary health facility using bivariate and multivariate analysis. RESULTS: Out of 152 babies, 75 (49.3%) had ABE: 73 had ABE at presentation while two developed ABE after admission. Bivariate analysis showed that body weight <2.5 kg, outside delivery, low maternal education, low socio-economic status, severe anaemia, glucose-6-phosphate dehydrogenase deficiency and metabolic acidosis were significantly associated with ABE. Multivariate analysis also showed that only outside delivery, weight <2.5 kg, presence of severe anaemia and acidosis were the predictors of ABE in this cohort of term babies. CONCLUSION: The identified predictors of ABE are modifiable and can be used to draw up screening tools for term babies at risk of ABE especially in the developing world.
OBJECTIVE: To determine predictors of acute bilirubinencephalopathy (ABE) among term infants presenting with moderate-to-severe hyperbilirubinaemia. METHODS: Babies with total serum bilirubin >15 mg/dl at the point of admission were studied in a Nigerian tertiary health facility using bivariate and multivariate analysis. RESULTS: Out of 152 babies, 75 (49.3%) had ABE: 73 had ABE at presentation while two developed ABE after admission. Bivariate analysis showed that body weight <2.5 kg, outside delivery, low maternal education, low socio-economic status, severe anaemia, glucose-6-phosphate dehydrogenase deficiency and metabolic acidosis were significantly associated with ABE. Multivariate analysis also showed that only outside delivery, weight <2.5 kg, presence of severe anaemia and acidosis were the predictors of ABE in this cohort of term babies. CONCLUSION: The identified predictors of ABE are modifiable and can be used to draw up screening tools for term babies at risk of ABE especially in the developing world.
Authors: Bolajoko O Olusanya; Folashade B Osibanjo; Adeniyi A Ajiboye; Oluwafemi E Ayodele; Adebanke A Odunsi; Serah M Olaifa; Abieyuwa A Emokpae Journal: J Matern Fetal Neonatal Med Date: 2017-03-20
Authors: Catherine Nyangabyaki-Twesigye; Edison Mworozi; Charles Namisi; Victoria Nakibuuka; Joshua Kayiwa; Robert Ssebunya; David Aggrey Mukose Journal: Afr Health Sci Date: 2020-03 Impact factor: 0.927
Authors: Tina M Slusher; Tara G Zamora; Duke Appiah; Judith U Stanke; Mark A Strand; Burton W Lee; Shane B Richardson; Elizabeth M Keating; Ashajoythi M Siddappa; Bolajoko O Olusanya Journal: BMJ Paediatr Open Date: 2017-11-25