Literature DB >> 20554470

Dynamic Network Connectivity: A new form of neuroplasticity.

Amy F T Arnsten1, Constantinos D Paspalas, Nao J Gamo, Yang Yang, Min Wang.   

Abstract

Prefrontal cortical (PFC) working memory functions depend on pyramidal cell networks that interconnect on dendritic spines. Recent research has revealed that the strength of PFC network connections can be rapidly and reversibly increased or decreased by molecular signaling events within slender, elongated spines: a process we term Dynamic Network Connectivity (DNC). This newly discovered form of neuroplasticity provides great flexibility in mental state, but also confers vulnerability and limits mental capacity. A remarkable number of genetic and/or environmental insults to DNC signaling cascades are associated with cognitive disorders such as schizophrenia and age-related cognitive decline. These insults can dysregulate network connections and erode higher cognitive abilities, leading to symptoms such as forgetfulness, susceptibility to interference, and disorganized thought and behavior. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20554470      PMCID： PMC2914830          DOI： 10.1016/j.tics.2010.05.003

Source DB:  PubMed          Journal:  Trends Cogn Sci        ISSN： 1364-6613            Impact factor:   20.229


  77 in total

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2.  Functional interplay between NMDA receptors, SK channels and voltage-gated Ca2+ channels regulates synaptic excitability in the medial prefrontal cortex.

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3.  Dynamically spreading frontal and cingulate deficits mapped in adolescents with schizophrenia.

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4.  A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists.

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Journal:  Biochem Pharmacol       Date:  2009-07-03       Impact factor: 5.858

5.  Psychosocial stress reversibly disrupts prefrontal processing and attentional control.

Authors:  C Liston; B S McEwen; B J Casey
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-12       Impact factor: 11.205

6.  Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress.

Authors:  Avis Brennan Hains; Mai Anh T Vu; Paul K Maciejewski; Christopher H van Dyck; Melissa Gottron; Amy F T Arnsten
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-11       Impact factor: 11.205

7.  Mapping the regulator of G protein signaling 4 (RGS4): presynaptic and postsynaptic substrates for neuroregulation in prefrontal cortex.

Authors:  Constantinos D Paspalas; Lynn D Selemon; Amy F T Arnsten
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Review 8.  The neuropsychopharmacology of fronto-executive function: monoaminergic modulation.

Authors:  T W Robbins; A F T Arnsten
Journal:  Annu Rev Neurosci       Date:  2009       Impact factor: 12.449

9.  Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis.

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  79 in total

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3.  Morphological and molecular changes in aging rat prelimbic prefrontal cortical synapses.

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Journal:  Neurobiol Aging       Date:  2012-06-22       Impact factor: 4.673

4.  Genome-Wide Analyses of Working-Memory Ability: A Review.

Authors:  E E M Knowles; S R Mathias; D R McKay; E Sprooten; John Blangero; Laura Almasy; D C Glahn
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Review 5.  Impact of aging brain circuits on cognition.

Authors:  Rachel D Samson; Carol A Barnes
Journal:  Eur J Neurosci       Date:  2013-06       Impact factor: 3.386

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7.  Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey.

Authors:  M E Young; D T Ohm; D Dumitriu; P R Rapp; J H Morrison
Journal:  Neuroscience       Date:  2014-05-20       Impact factor: 3.590

Review 8.  Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia.

Authors:  Amy F T Arnsten
Journal:  Int J Dev Neurosci       Date:  2011-02-21       Impact factor: 2.457

Review 9.  Anteroventral bed nuclei of the stria terminalis neurocircuitry: Towards an integration of HPA axis modulation with coping behaviors - Curt Richter Award Paper 2017.

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Review 10.  Dendritic spine changes associated with normal aging.

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Journal:  Neuroscience       Date:  2012-10-13       Impact factor: 3.590
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