Literature DB >> 20554468

Development of a cost-effective torsional unit for rodent long bone assessment.

M M Saunders1, R B Burger, B Kalantari, A D Nichols, C Witman.   

Abstract

Thorough mechanical testing of rodent bones requires an understanding of bone behavior in a variety of loading modes including tension, compression, bending and shear. While these tests are easily conducted with single axis mechanical testing machines, it may also be desirable to determine torsional properties of bone. Although higher-end materials testing machines will enable torsional and/or rotational testing, simpler, less expensive systems rarely offer these capabilities. In this work, we illustrate the development of a torsional system that uses a simple rack and pinion concept to deliver a rotary motion to bones given the linear motion of a testing machine. As the bone field becomes increasingly interdisciplinary, more biologists and non-test engineers need cost-effective mechanical testing capabilities and the torsional system described here has proven to be more than adequate for standard biomechanical testing requirements. Furthermore, given the small-scale size of rodent long bones, a series of potting/testing fixtures were developed that enabled preparation and handling of the specimens without incurring damage to the bone shafts. Once fabricated the system was used to destructively load mice humeri and femurs and quantify torsional properties. 2010 IPEM. Published by Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20554468      PMCID: PMC2914169          DOI: 10.1016/j.medengphy.2010.05.004

Source DB:  PubMed          Journal:  Med Eng Phys        ISSN: 1350-4533            Impact factor:   2.242


  10 in total

1.  In vitro sodium fluoride exposure decreases torsional and bending strength and increases ductility of mouse femora.

Authors:  M J Silva; S R Ulrich
Journal:  J Biomech       Date:  2000-02       Impact factor: 2.712

2.  Development of a cost-effective loading machine for biomechanical evaluation of mouse transgenic models.

Authors:  M M Saunders; H J Donahue
Journal:  Med Eng Phys       Date:  2004-09       Impact factor: 2.242

3.  An improved method to assess torsional properties of rodent long bones.

Authors:  Ara Nazarian; Vahid Entezari; Vartan Vartanians; Ralph Müller; Brian D Snyder
Journal:  J Biomech       Date:  2009-05-17       Impact factor: 2.712

4.  Measurement of the mechanical properties of bone: a recent history.

Authors:  John Currey
Journal:  Clin Orthop Relat Res       Date:  2009-03-14       Impact factor: 4.176

5.  Design and validation of a testing system to assess torsional cancellous bone failure in conjunction with time-lapsed micro-computed tomographic imaging.

Authors:  Ara Nazarian; Michael Bauernschmitt; Christian Eberle; Diego Meier; Ralph Müller; Brian D Snyder
Journal:  J Biomech       Date:  2008-11-05       Impact factor: 2.712

6.  Growing C57Bl/6 mice increase whole bone mechanical properties by increasing geometric and material properties.

Authors:  M D Brodt; C B Ellis; M J Silva
Journal:  J Bone Miner Res       Date:  1999-12       Impact factor: 6.741

7.  Torsional testing and peripheral quantitative computed tomography in rat humerus.

Authors:  P M Lind; L Lind; S Larsson; J Orberg
Journal:  Bone       Date:  2001-09       Impact factor: 4.398

8.  Long bone geometry and strength in adult BMP-5 deficient mice.

Authors:  B Mikić; M C van der Meulen; D M Kingsley; D R Carter
Journal:  Bone       Date:  1995-04       Impact factor: 4.398

9.  Improved method for analysis of whole bone torsion tests.

Authors:  M E Levenston; G S Beaupré; M C van der Meulen
Journal:  J Bone Miner Res       Date:  1994-09       Impact factor: 6.741

10.  The effect of immobilization on the torsional strength of the rat tibia.

Authors:  V Lepola; K Väänänen; P Jalovaara
Journal:  Clin Orthop Relat Res       Date:  1993-12       Impact factor: 4.176

  10 in total

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