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Literature DB >> 20554401

In vitro antimicrobial activity of gallium maltolate against virulent Rhodococcus equi.

Michelle Coleman¹, Kyle Kuskie, Mei Liu, Keith Chaffin, Melissa Libal, Steeve Giguère, Lawrence Bernstein, Noah Cohen.

Abstract

The objective of this study was to determine the in vitro antimicrobial activity of gallium maltolate (GaM) against Rhodococcus equi. A total of 98 virulent bacterial isolates from equine clinical cases were examined, of which 19 isolates were known to be resistant to macrolides and rifampin. Isolates were cultured with various concentrations of GaM and minimal inhibitory concentration (MIC) values were determined after 24 and 48 h. Both the MIC(50) and the MIC(90) after 24h of growth were 558 ng/mL (8 μM) and after 48 h of growth were 2230 ng/mL (32 μM). There were no apparent differences between MICs of macrolide-resistant and macrolide-susceptible isolates.

Entities: Chemical Species

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Year: 2010 PMID： 20554401 DOI： 10.1016/j.vetmic.2010.05.027

Source DB: PubMed Journal: Vet Microbiol ISSN： 0378-1135 Impact factor: 3.293

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Cited

7 in total

1. In vitro and in vivo antimicrobial activities of gallium nitrate against multidrug-resistant Acinetobacter baumannii.

Authors: Luísa C S Antunes; Francesco Imperi; Fabrizia Minandri; Paolo Visca
Journal: Antimicrob Agents Chemother Date: 2012-09-10 Impact factor: 5.191

2. In vitro susceptibility of equine-obtained isolates of Corynebacterium pseudotuberculosis to gallium maltolate and 20 other antimicrobial agents.

Authors: T E Norman; M Batista; S D Lawhon; S Zhang; K R Kuskie; A K Swinford; L R Bernstein; N D Cohen
Journal: J Clin Microbiol Date: 2014-05-14 Impact factor: 5.948

Review 3. Epidemiology and Molecular Basis of Multidrug Resistance in Rhodococcus equi.

Authors: Sonsiray Álvarez-Narváez; Laura Huber; Steeve Giguère; Kelsey A Hart; Roy D Berghaus; Susan Sanchez; Noah D Cohen
Journal: Microbiol Mol Biol Rev Date: 2021-04-14 Impact factor: 11.056

4. Gain-of-Function Mutations in Acid Stress Response (evgS) Protect Escherichia coli from Killing by Gallium Nitrate, an Antimicrobial Candidate.

Authors: Jie Zeng; Liwen Wu; Zhou Liu; Yihua Lv; Jinzhi Feng; Weijie Wang; Yunxin Xue; Dai Wang; Jiabin Li; Karl Drlica; Xilin Zhao
Journal: Antimicrob Agents Chemother Date: 2021-02-17 Impact factor: 5.191

In vitro antimicrobial activity of gallium maltolate against virulent Rhodococcus equi.

1. In vitro and in vivo antimicrobial activities of gallium nitrate against multidrug-resistant Acinetobacter baumannii.

2. In vitro susceptibility of equine-obtained isolates of Corynebacterium pseudotuberculosis to gallium maltolate and 20 other antimicrobial agents.

Review 3. Epidemiology and Molecular Basis of Multidrug Resistance in Rhodococcus equi.

4. Gain-of-Function Mutations in Acid Stress Response (evgS) Protect Escherichia coli from Killing by Gallium Nitrate, an Antimicrobial Candidate.

5. Gallium maltolate as an alternative to macrolides for treatment of presumed Rhodococcus equi pneumonia in foals.

6. Insights into the chemistry of the amphibactin-metal (M³⁺) interaction and its role in antibiotic resistance.

7. A Common Practice of Widespread Antimicrobial Use in Horse Production Promotes Multi-Drug Resistance.

In vitro antimicrobial activity of gallium maltolate against virulent Rhodococcus equi.

1. In vitro and in vivo antimicrobial activities of gallium nitrate against multidrug-resistant Acinetobacter baumannii.

2. In vitro susceptibility of equine-obtained isolates of Corynebacterium pseudotuberculosis to gallium maltolate and 20 other antimicrobial agents.

Review 3. Epidemiology and Molecular Basis of Multidrug Resistance in Rhodococcus equi.

4. Gain-of-Function Mutations in Acid Stress Response (evgS) Protect Escherichia coli from Killing by Gallium Nitrate, an Antimicrobial Candidate.

5. Gallium maltolate as an alternative to macrolides for treatment of presumed Rhodococcus equi pneumonia in foals.

6. Insights into the chemistry of the amphibactin-metal (M3+) interaction and its role in antibiotic resistance.

7. A Common Practice of Widespread Antimicrobial Use in Horse Production Promotes Multi-Drug Resistance.

6. Insights into the chemistry of the amphibactin-metal (M³⁺) interaction and its role in antibiotic resistance.