Literature DB >> 20553768

Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates.

Susan Wyllie1, Goutam Mandal, Neeloo Singh, Shyam Sundar, Alan H Fairlamb, Mitali Chatterjee.   

Abstract

Enhancement of the anti-oxidant metabolism of Leishmania parasites, dependent upon the unique dithiol trypanothione, has been implicated in laboratory-generated antimony resistance. Here, the role of the trypanothione-dependent anti-oxidant pathway is studied in antimony-resistant clinical isolates. Elevated levels of tryparedoxin and tryparedoxin peroxidase, key enzymes in hydroperoxide detoxification, were observed in antimonial resistant parasites resulting in an increased metabolism of peroxides. These data suggest that enhanced anti-oxidant defences may play a significant role in clinical resistance to antimonials. Copyright 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20553768      PMCID： PMC3428625          DOI： 10.1016/j.molbiopara.2010.05.015

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


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