| Literature DB >> 20552710 |
Alfin D N Vaz1, Wei Wei Wang, Andrew J Bessire, Raman Sharma, Anne E Hagen.
Abstract
A simple procedure is described to identify acyl-glucuronides by coupled liquid chromatography/mass spectrometry after derivatization to a hydroxamic acid with hydroxylamine. The reaction specificity obviates the need for isolation of the acyl-glucuronide from an extract. Glucuronides derived from carbamic acids, and alkyl- and aromatic amines, are inert to the derivatization reaction conditions, making the hydroxamic acid derivative a fingerprint for acyl-glucuronides. Copyright 2010 John Wiley & Sons, Ltd.Entities:
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Year: 2010 PMID： 20552710 DOI： 10.1002/rcm.4621
Source DB: PubMed Journal: Rapid Commun Mass Spectrom ISSN： 0951-4198 Impact factor: 2.419