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Literature DB >> 2055248

Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat.

Abstract

Peripheral administration of cholecystokinin tetrapeptide (CCK-4) at non-sedative doses (25-50 micrograms/kg) decreased the exploratory activity of rats in an elevated plus-maze. This effect was antagonized by treatment with CCK receptor antagonists proglumide (1 and 10 mg/kg), lorglumide (0.1 and 1 mg/kg), L 365,260 (10 micrograms/kg) and devazepide (1 mg/kg). The results suggest that the exploratory behaviour of rats can be altered by pharmacological manipulations at CCK-B receptors.

Entities: Chemical Gene Species

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Year: 1991 PMID： 2055248 DOI： 10.1016/0014-2999(91)90156-k

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

16 in total

1. Wiring and volume transmission in rat amygdala. Implications for fear and anxiety.

Authors: Miguel Pérez de la Mora; Kirsten X Jacobsen; Minerva Crespo-Ramírez; Candy Flores-Gracia; Kjell Fuxe
Journal: Neurochem Res Date: 2008-05-13 Impact factor: 3.996

2. CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats.

Authors: M Lemaire; G A Böhme; O Piot; B P Roques; J C Blanchard
Journal: Psychopharmacology (Berl) Date: 1994-08 Impact factor: 4.530

3. Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole.

Authors: M Derrien; C Durieux; B P Roques
Journal: Br J Pharmacol Date: 1994-03 Impact factor: 8.739

4. Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice.

Authors: Sirli Raud; Kertu Rünkorg; Alar Veraksits; Ain Reimets; Aleksei Nelovkov; Urho Abramov; Toshimitsu Matsui; Michel Bourin; Vallo Volke; Sulev Kõks; Eero Vasar
Journal: Psychopharmacology (Berl) Date: 2003-04-23 Impact factor: 4.530

5. The benzodiazepine antagonist flumazenil blocks the effects of CCK receptor agonists and antagonists in the elevated plus-maze.

Authors: P Chopin; M Briley
Journal: Psychopharmacology (Berl) Date: 1993 Impact factor: 4.530

6. Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein.

Authors: E Vasar; E Peuranen; J Harro; A Lang; L Oreland; P T Männistö
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1993-07 Impact factor: 3.000

Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat.

1. Wiring and volume transmission in rat amygdala. Implications for fear and anxiety.

2. CCK-A and CCK-B selective receptor agonists and antagonists modulate olfactory recognition in male rats.

3. Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole.

4. Targeted mutation of CCK2 receptor gene modifies the behavioural effects of diazepam in female mice.

5. The benzodiazepine antagonist flumazenil blocks the effects of CCK receptor agonists and antagonists in the elevated plus-maze.

6. Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein.

7. Cholecystokinin and psychiatric disorders : role in aetiology and potential of receptor antagonists in therapy.

8. Pentagastrin induced panic attacks: enhanced sensitivity in panic disorder patients.

9. Modelling anxiety in humans for drug development.

10. The CCK-system underpins novelty-seeking behavior in the rat: gene expression and pharmacological analyses.