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Literature DB >> 20552297

Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses.

Bill X Wu¹, Christopher J Clarke, Yusuf A Hannun.

Abstract

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond in sphingomyelin (SM) to form ceramide and phosphocholine. In mammals, three Mg(2+)-dependent neutral SMases termed nSMase1, nSMase2 and nSMase3 have been identified. Among the three enzymes, nSMase2 is the most studied and has been implicated in multiple physiological responses including cell growth arrest, apoptosis, development and inflammation. In this review, we summarize recent findings for the cloned nSMases and discuss the insights for their roles in regulation ceramide metabolism and cellular signaling pathway.

Entities: CellLine Chemical Disease Gene Species

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Year: 2010 PMID： 20552297 PMCID： PMC3405913 DOI： 10.1007/s12017-010-8120-z

Source DB: PubMed Journal: Neuromolecular Med ISSN： 1535-1084 Impact factor: 3.843

87 in total

1. Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma.

Authors: Norma Marchesini; Jeffrey A Jones; Yusuf A Hannun
Journal: Biochim Biophys Acta Date: 2007-11-08

2. Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.

Authors: Woo Jae Kim; Ross A Okimoto; Louise E Purton; Meagan Goodwin; Sara M Haserlat; Farshid Dayyani; David A Sweetser; Andrea I McClatchey; Olivier A Bernard; A Thomas Look; Daphne W Bell; David T Scadden; Daniel A Haber
Journal: Blood Date: 2008-02-25 Impact factor: 22.113

Review 3. Principles of bioactive lipid signalling: lessons from sphingolipids.

Authors: Yusuf A Hannun; Lina M Obeid
Journal: Nat Rev Mol Cell Biol Date: 2008-02 Impact factor: 94.444

4. Aging in rat causes hepatic hyperresposiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2.

Authors: Kristina Rutkute; Alexander A Karakashian; Natalia V Giltiay; Aneta Dobierzewska; Mariana N Nikolova-Karakashian
Journal: Hepatology Date: 2007-10 Impact factor: 17.425

5. Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies.

Authors: Chad A Corcoran; Qin He; Suriyan Ponnusamy; Besim Ogretmen; Ying Huang; M Saeed Sheikh
Journal: Mol Cancer Res Date: 2008-05 Impact factor: 5.852

Review 6. The sphingolipid salvage pathway in ceramide metabolism and signaling.

Authors: Kazuyuki Kitatani; Jolanta Idkowiak-Baldys; Yusuf A Hannun
Journal: Cell Signal Date: 2007-12-14 Impact factor: 4.315

7. Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation.

Authors: Kristina Rutkute; Reto H Asmis; Mariana N Nikolova-Karakashian
Journal: J Lipid Res Date: 2007-08-10 Impact factor: 5.922

Review 8. Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases.

Authors: Nabil Matmati; Yusuf A Hannun
Journal: J Lipid Res Date: 2008-02-27 Impact factor: 5.922

Review 9. The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease.

Authors: E H Schuchman
Journal: J Inherit Metab Dis Date: 2007-07-12 Impact factor: 4.982

Review 10. Role of neutral sphingomyelinases in aging and inflammation.

Authors: Mariana Nikolova-Karakashian; Alexander Karakashian; Kristina Rutkute
Journal: Subcell Biochem Date: 2008

57 in total

1. Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines.

Authors: Simone Filosto; Majid Ashfaq; Samuel Chung; William Fry; Tzipora Goldkorn
Journal: J Biol Chem Date: 2011-11-10 Impact factor: 5.157

Review 2. Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.

Authors: Alfred H Merrill
Journal: Chem Rev Date: 2011-09-26 Impact factor: 60.622

Review 3. Membrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells.

Authors: Peter Thomas; Yefei Pang
Journal: Neuroendocrinology Date: 2012-09-14 Impact factor: 4.914

Review 4. Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.

Authors: Tzipora Goldkorn; Simone Filosto; Samuel Chung
Journal: Antioxid Redox Signal Date: 2014-07-01 Impact factor: 8.401

Review 5. The neutral sphingomyelinase family: identifying biochemical connections.

Authors: Christopher J Clarke; Bill X Wu; Yusuf A Hannun
Journal: Adv Enzyme Regul Date: 2010-10-28

Review 6. Evolving concepts in cancer therapy through targeting sphingolipid metabolism.

Authors: Jean-Philip Truman; Mónica García-Barros; Lina M Obeid; Yusuf A Hannun
Journal: Biochim Biophys Acta Date: 2013-12-30

7. Theoretical investigations into the intermolecular hydrogen-bonding interactions of N-(hydroxymethyl)acetamide dimers.

Authors: Hai-Fei Tang; Hua Zhong; Ling-Ling Zhang; Ming-Xing Gong; Shu-Qin Song; Qing-Ping Tian
Journal: J Mol Model Date: 2018-05-31 Impact factor: 1.810