Literature DB >> 20552113

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.

Elena M Sánchez-Fernández1, Rocío Rísquez-Cuadro, Maud Chasseraud, Ahmed Ahidouch, Carmen Ortiz Mellet, Halima Ouadid-Ahidouch, José M García Fernández.   

Abstract

sp(2)-Iminosugar-type castanospermine analogues bearing an alpha-configured N-, S-, or C-linked pseudoanomeric group have been designed as selective inhibitors of the neutral alpha-glucosidases involved in N-glycoprotein processing; evaluation in breast cancer cell growth indicated a significant antiproliferative potential that was dependent on the nature of the pseudoanomeric group.

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Year:  2010        PMID： 20552113     DOI： 10.1039/c0cc00446d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells.

Authors:  Ghada Allan; Halima Ouadid-Ahidouch; Elena M Sanchez-Fernandez; Rocío Risquez-Cuadro; José M Garcia Fernandez; Carmen Ortiz-Mellet; Ahmed Ahidouch
Journal:  PLoS One       Date:  2013-10-04       Impact factor: 3.240

Review 2.  Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer.

Authors:  Andréia Vasconcelos-Dos-Santos; Isadora A Oliveira; Miguel Clodomiro Lucena; Natalia Rodrigues Mantuano; Stephen A Whelan; Wagner Barbosa Dias; Adriane Regina Todeschini
Journal:  Front Oncol       Date:  2015-06-25       Impact factor: 6.244

3.  Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.

Authors:  Elena Lenci; Riccardo Innocenti; Alessio Biagioni; Gloria Menchi; Francesca Bianchini; Andrea Trabocchi
Journal:  Molecules       Date:  2016-10-20       Impact factor: 4.411

4.  Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease.

Authors:  Teresa Mena-Barragán; M Isabel García-Moreno; Alen Sevšek; Tetsuya Okazaki; Eiji Nanba; Katsumi Higaki; Nathaniel I Martin; Roland J Pieters; José M García Fernández; Carmen Ortiz Mellet
Journal:  Molecules       Date:  2018-04-17       Impact factor: 4.411

5.  Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids.

Authors:  Elena M Sánchez-Fernández; M Isabel García-Moreno; Raquel García-Hernández; José M Padrón; José M García Fernández; Francisco Gamarro; Carmen Ortiz Mellet
Journal:  Molecules       Date:  2019-08-08       Impact factor: 4.411

6.  Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy.

Authors:  Fátima Cano-Cano; Elena Alcalde-Estévez; Laura Gómez-Jaramillo; Marta Iturregui; Elena M Sánchez-Fernández; José M García Fernández; Carmen Ortiz Mellet; Antonio Campos-Caro; Cristina López-Tinoco; Manuel Aguilar-Diosdado; Ángela M Valverde; Ana I Arroba
Journal:  Front Immunol       Date:  2021-03-18       Impact factor: 7.561

7.  Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ.

Authors:  Laura Gómez-Jaramillo; Fátima Cano-Cano; Elena M Sánchez-Fernández; Carmen Ortiz Mellet; José M García-Fernández; Martín Alcalá; Fabiola Álvarez-Gallego; Marta Iturregui; María Del Carmen González-Montelongo; Antonio Campos-Caro; Ana I Arroba; Manuel Aguilar-Diosdado
Journal:  Int J Mol Sci       Date:  2022-07-30       Impact factor: 6.208

8.  Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics.

Authors:  Irene Herrera-González; Manuel González-Cuesta; M Isabel García-Moreno; José Manuel García Fernández; Carmen Ortiz Mellet
Journal:  ACS Omega       Date:  2022-06-16

9.  D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent.

Authors:  A Minutolo; S Grelli; F Marino-Merlo; F M Cordero; A Brandi; B Macchi; A Mastino
Journal:  Cell Death Dis       Date:  2012-07-26       Impact factor: 8.469

10.  Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti-Inflammatory Properties.

Authors:  Elena M Sánchez-Fernández; Raquel García-Hernández; Francisco Gamarro; Ana I Arroba; Manuel Aguilar-Diosdado; José M Padrón; José M García Fernández; Carmen Ortiz Mellet
Journal:  Molecules       Date:  2021-12-11       Impact factor: 4.411
  10 in total

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