Literature DB >> 20551110

Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis.

José Ramón Lamas1, Luis Rodríguez-Rodríguez, Jezabel Varadé, Pedro López-Romero, Pilar Tornero-Esteban, Lydia Abasolo, Elena Urcelay, Benjamín Fernández-Gutiérrez.   

Abstract

OBJECTIVE: To analyze the influence of IL6R rs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA).
METHODS: Patients with RA (n = 281) were followed for a median of 4.2 years. A total of 1143 disease activity measurements using the 28-joint count Disease Activity Score (DAS28) were performed. A mixed-effect model was used to analyze the measurements.
RESULTS: A statistically significant interaction was observed between IL6R rs8192284 polymorphism and the presence of anticyclic citrullinated peptide (anti-CCP) antibodies (p = 0.008). An inverse relationship between the polymorphism and DAS28 was observed depending on anti-CCP status.
CONCLUSION: The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity.

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Year:  2010        PMID： 20551110     DOI： 10.3899/jrheum.091455

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  6 in total

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Authors:  T H A Tvedt; R Hovland; G Tsykunova; A B Ahmed; T Gedde-Dahl; Ø Bruserud
Journal:  Clin Exp Immunol       Date:  2018-04-01       Impact factor: 4.330

2.  A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis.

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Authors:  Hui Xu; Jun Liu; Mengyuan Niu; Shiyu Song; Lulu Wei; Gang Chen; Yibing Ding; Yong Wang; Zhonglan Su; Hongwei Wang
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4.  Relationship Between Interleukin-6 -174G/C Genetic Variant and Efficacy of Methotrexate Treatment in Psoriatic Arthritis Patients.

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Journal:  Pharmgenomics Pers Med       Date:  2021-01-28

5.  Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis.

Authors:  Maria Lopez-Lasanta; Antonio Julià; Joan Maymó; Benjamín Fernández-Gutierrez; Inmaculada Ureña-Garnica; Francisco J Blanco; Juan D Cañete; Mercedes Alperi-López; Alex Olivè; Héctor Corominas; Jesus Tornero; Alba Erra; Miriam Almirall; Nuria Palau; Ana Ortiz; Gabriela Avila; Luis Rodriguez-Rodriguez; Arnald Alonso; Raül Tortosa; Isidoro Gonzalez-Alvaro; Sara Marsal
Journal:  Arthritis Res Ther       Date:  2015-09-04       Impact factor: 5.156

Review 6.  Rheumatoid Arthritis: The Stride from Research to Clinical Practice.

Authors:  Ill-Min Chung; Sarada Ketharnathan; Muthu Thiruvengadam; Govindasamy Rajakumar
Journal:  Int J Mol Sci       Date:  2016-06-08       Impact factor: 5.923
  6 in total

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