INTRODUCTION: Several methods have been used to treat cerebral vasospasm, which is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). Here, we examined the effectiveness and safety of intra-arterial injection of milrinone for the treatment of vasospasm. METHODS: Consecutive patients with angiographically confirmed vasospasm received intra-arterial milrinone between January 2006 and December 2007. The improvement in diameter of vessel (in millimeters) following treatment was assessed by paired t test for statistical significance. The angiographic improvement of supraclinoid internal carotid artery, M1 segment of middle cerebral artery, and A1 and A2 segment of anterior cerebral artery was compared with the modified Rankin score of the patients at discharge. RESULTS: A total of 15 milrinone treatments were performed in 14 patients (11 females and 3 males) with mean age of 52.7 years (31-68 years). There was significant angiographic improvement after milrinone therapy (p < 0.0001). CONCLUSION: Intra-arterial milrinone was a safe and effective treatment of cerebral vasospasm following aneurysmal SAH.
INTRODUCTION: Several methods have been used to treat cerebral vasospasm, which is a major cause of morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (SAH). Here, we examined the effectiveness and safety of intra-arterial injection of milrinone for the treatment of vasospasm. METHODS: Consecutive patients with angiographically confirmed vasospasm received intra-arterial milrinone between January 2006 and December 2007. The improvement in diameter of vessel (in millimeters) following treatment was assessed by paired t test for statistical significance. The angiographic improvement of supraclinoid internal carotid artery, M1 segment of middle cerebral artery, and A1 and A2 segment of anterior cerebral artery was compared with the modified Rankin score of the patients at discharge. RESULTS: A total of 15 milrinone treatments were performed in 14 patients (11 females and 3 males) with mean age of 52.7 years (31-68 years). There was significant angiographic improvement after milrinone therapy (p < 0.0001). CONCLUSION: Intra-arterial milrinone was a safe and effective treatment of cerebral vasospasm following aneurysmalSAH.
Authors: Anna Terry; Gregory Zipfel; Eric Milner; DeWitte T Cross; Christopher J Moran; Michael N Diringer; Ralph G Dacey; Colin P Derdeyn Journal: Neurosurg Focus Date: 2006-09-15 Impact factor: 4.047
Authors: K Khajavi; I Ayzman; D Shearer; S C Jones; J H Levy; R A Prayson; C I Skibinski; J F Hahn; D Chyatte Journal: Neurosurgery Date: 1997-02 Impact factor: 4.654
Authors: Neeraj Badjatia; Mehmet A Topcuoglu; Johnny C Pryor; James D Rabinov; Christopher S Ogilvy; Bob S Carter; Guy A Rordorf Journal: AJNR Am J Neuroradiol Date: 2004-05 Impact factor: 3.825
Authors: Jan W Dankbaar; Mienke Rijsdijk; Irene C van der Schaaf; Birgitta K Velthuis; Marieke J H Wermer; Gabriel J E Rinkel Journal: Neuroradiology Date: 2009-07-22 Impact factor: 2.804
Authors: Thomas D Bernier; Michael J Schontz; Saef Izzy; David Y Chung; Sarah E Nelson; Thabele M Leslie-Mazwi; Galen V Henderson; Hormuzdiyar Dasenbrock; Nirav Patel; Mohammad A Aziz-Sultan; Steven Feske; Rose Du; Yasser B Abulhasan; Mark R Angle Journal: J Neurosurg Anesthesiol Date: 2021-07-01 Impact factor: 3.969