| Literature DB >> 20547805 |
M Mar Rodríguez1, F Javier Pastor, Valentina Salas, Enrique Calvo, Emilio Mayayo, Josep Guarro.
Abstract
The histopathology of clinical isolates of Scedosporium apiospermum, Scedosporium boydii, and Scedosporium aurantiacum in immunosuppressed mice was evaluated. The organs most affected were the brain, kidneys, and spleen. S. aurantiacum produced more tissue damage than the other two species. Amphotericin B (AMB) was ineffective in the treatment of murine infections caused by such isolates, and posaconazole and voriconazole showed efficacy that correlated with the in vitro susceptibility data.Entities:
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Year: 2010 PMID: 20547805 PMCID: PMC2935030 DOI: 10.1128/AAC.00046-10
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191