Much Ado about Nogo.

Three proteins in mature myelin (Nogo, MAG, and OMgp) have been purported to be critical in causing both regenerative failure and minimal sprouting after CNS injury. However, the role of this repulsive trio in vivo has been controversial. Lee et al., in this issue of Neuron, provide evidence that genetically deleting all three major myelin inhibitors either singly or all together does not result in regeneration after spinal cord lesion, and the minimal sprouting that occurs, when it does, is insufficient to restore meaningful behavior. Copyright 2010 Elsevier Inc. All rights reserved.