Literature DB >> 2054572

Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer's disease.

K Wilson1, D Bowen, P Francis, P Tyrrell.   

Abstract

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

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Year:  1991        PMID： 2054572     DOI： 10.1192/bjp.158.4.558

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


  3 in total

1.  Selective excitation of subtypes of neocortical interneurons by nicotinic receptors.

Authors:  J T Porter; B Cauli; K Tsuzuki; B Lambolez; J Rossier; E Audinat
Journal:  J Neurosci       Date:  1999-07-01       Impact factor: 6.167

2.  A neurochemical approach for studying response to acetylcholine in Alzheimer's disease.

Authors:  J T Alder; I P Chessell; D M Bowen
Journal:  Neurochem Res       Date:  1995-07       Impact factor: 3.996

3.  Differential cholinergic regulation in Alzheimer's patients compared to controls following chronic blockade with scopolamine: a SPECT study.

Authors:  T Sunderland; G Esposito; S E Molchan; R Coppola; D W Jones; J Gorey; J T Little; M Bahro; D R Weinberger
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530
  3 in total

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