OBJECTIVES: To analyze the frequency of mutations associated with Parkinson's disease (PD) in a general PD population compared to patients with PD selected for deep brain stimulation (DBS) and evaluate the outcome of surgery. MATERIAL AND METHODS: A total of 630 consecutive patients with PD were genetically screened, and 60 had DBS surgery, 37 subthalamic nucleus (STN), 21 ventrointermediate nucleus of thalamus (VIM), and two globus pallidus internus (GPi). RESULTS: Mutations in LRRK2, PRKN, and PINK1 were found: the first two of these being overrepresented in STN-operated patients, but none being found in VIM-operated patients. Clinical outcome of the surgery was similar in patients with mutations compared to those without. CONCLUSIONS: In a consecutive PD population, patients treated with STN-DBS are overrepresented for PD-related mutations and they seem to benefit from DBS as well as patients without mutations.
OBJECTIVES: To analyze the frequency of mutations associated with Parkinson's disease (PD) in a general PD population compared to patients with PD selected for deep brain stimulation (DBS) and evaluate the outcome of surgery. MATERIAL AND METHODS: A total of 630 consecutive patients with PD were genetically screened, and 60 had DBS surgery, 37 subthalamic nucleus (STN), 21 ventrointermediate nucleus of thalamus (VIM), and two globus pallidus internus (GPi). RESULTS: Mutations in LRRK2, PRKN, and PINK1 were found: the first two of these being overrepresented in STN-operated patients, but none being found in VIM-operated patients. Clinical outcome of the surgery was similar in patients with mutations compared to those without. CONCLUSIONS: In a consecutive PD population, patients treated with STN-DBS are overrepresented for PD-related mutations and they seem to benefit from DBS as well as patients without mutations.
Authors: C Perandones; N Aráoz Olivos; G B Raina; L A Pellene; J C Giugni; D S Calvo; M Radrizzani; F Piedimonte; F E Micheli Journal: J Neurol Date: 2014-11-20 Impact factor: 4.849
Authors: Caryl E Sortwell; Mallory L Hacker; David Luke Fischer; Peter E Konrad; Thomas L Davis; Joseph S Neimat; Lily Wang; Yanna Song; Zach R Mattingly; Allyson Cole-Strauss; Jack W Lipton; P David Charles Journal: Neuromodulation Date: 2022-06-14
Authors: Emil K Gustavsson; Joanne Trinh; Marna McKenzie; Stephanie Bortnick; Maria Skaalum Petersen; Matthew J Farrer; Jan O Aasly Journal: Mov Disord Clin Pract Date: 2017-05-23
Authors: Aikaterina Angeli; Niccolo E Mencacci; Raquel Duran; Iciar Aviles-Olmos; Zinovia Kefalopoulou; Joseph Candelario; Sarah Rusbridge; Jennifer Foley; Priyanka Pradhan; Marjan Jahanshahi; Ludvic Zrinzo; Marwan Hariz; Nicholas W Wood; John Hardy; Patricia Limousin; Tom Foltynie Journal: Mov Disord Date: 2013-07-01 Impact factor: 10.338