OBJECTIVES: The extent to which psychotic disorders fall into distinct diagnostic categories or can be regarded as lying on a single continuum is controversial. We compared lateral ventricle volumes between a large sample of patients with first-episode schizophrenia or bipolar disorder and a healthy control group from the same neighbourhood. METHODS: Population-based MRI study with 88 first-episode psychosis (FEP) patients, grouped into those with schizophrenia/schizophreniform disorder (N=62), bipolar disorder (N=26) and 94 controls. RESULTS: Right and left lateral ventricular and right temporal horn volumes were larger in FEP subjects than controls. Within the FEP sample, post-hoc tests revealed larger left lateral ventricles and larger right and left temporal horns in schizophrenia subjects relative to controls, while there was no difference between patients with bipolar disorder and controls. None of the findings was attributable to effects of antipsychotics. CONCLUSIONS: This large-sample population-based MRI study showed that neuroanatomical abnormalities in subjects with schizophrenia relative to controls from the same neighbourhood are evident at the first episode of illness, but are not detectable in bipolar disorder patients. These data are consistent with a model of psychosis in which early brain insults of neurodevelopmental origin are more relevant to schizophrenia than to bipolar disorder.
OBJECTIVES: The extent to which psychotic disorders fall into distinct diagnostic categories or can be regarded as lying on a single continuum is controversial. We compared lateral ventricle volumes between a large sample of patients with first-episode schizophrenia or bipolar disorder and a healthy control group from the same neighbourhood. METHODS: Population-based MRI study with 88 first-episode psychosis (FEP) patients, grouped into those with schizophrenia/schizophreniform disorder (N=62), bipolar disorder (N=26) and 94 controls. RESULTS: Right and left lateral ventricular and right temporal horn volumes were larger in FEP subjects than controls. Within the FEP sample, post-hoc tests revealed larger left lateral ventricles and larger right and left temporal horns in schizophrenia subjects relative to controls, while there was no difference between patients with bipolar disorder and controls. None of the findings was attributable to effects of antipsychotics. CONCLUSIONS: This large-sample population-based MRI study showed that neuroanatomical abnormalities in subjects with schizophrenia relative to controls from the same neighbourhood are evident at the first episode of illness, but are not detectable in bipolar disorderpatients. These data are consistent with a model of psychosis in which early brain insults of neurodevelopmental origin are more relevant to schizophrenia than to bipolar disorder.
Authors: Erin E Edmiston; Fei Wang; Jessica H Kalmar; Fay Y Womer; Lara G Chepenik; Brian Pittman; Ralitza Gueorguieva; Esther Hur; Linda Spencer; Lawrence H Staib; R Todd Constable; Robert K Fulbright; Xenophon Papademetris; Hilary P Blumberg Journal: Psychiatry Res Date: 2011-10-30 Impact factor: 3.222
Authors: Matthew S Conrad; Bradley P Sutton; Ryan Larsen; William G Van Alstine; Rodney W Johnson Journal: Brain Behav Immun Date: 2015-05-09 Impact factor: 7.217
Authors: Joana A Palha; Nadine C Santos; Fernanda Marques; João Sousa; João Bessa; Rui Miguelote; Nuno Sousa; Paulo Belmonte-de-Abreu Journal: Front Cell Neurosci Date: 2012-08-08 Impact factor: 5.505
Authors: Mireille Nieuwenhuis; Hugo G Schnack; Neeltje E van Haren; Julia Lappin; Craig Morgan; Antje A Reinders; Diana Gutierrez-Tordesillas; Roberto Roiz-Santiañez; Maristela S Schaufelberger; Pedro G Rosa; Marcus V Zanetti; Geraldo F Busatto; Benedicto Crespo-Facorro; Patrick D McGorry; Dennis Velakoulis; Christos Pantelis; Stephen J Wood; René S Kahn; Janaina Mourao-Miranda; Paola Dazzan Journal: Neuroimage Date: 2016-07-12 Impact factor: 6.556