Literature DB >> 20545309

In situ measurement of the enantiomeric excess of alcohols and amines under asymmetric reduction reaction by 1H NMR.

Xiaoxia Ye1, Xinxiang Lei, Zhenfei Chen, Lixue Zhang, Anjiang Zhang.   

Abstract

(1)H NMR, in situ, determines the enantiomeric excess of reduced chiral alcohols or amines without adding any auxiliary and workup. The percent ee data determined by this method agree well with those given by HPLC. This approach may be potentially applicable to many asymmetric reductions.

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Year:  2010        PMID: 20545309     DOI: 10.1021/ol1011899

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Synthesis of Tripeptide Derivatives with Three Stereogenic Centers and Chiral Recognition Probed by Tetraaza Macrocyclic Chiral Solvating Agents Derived from d-Phenylalanine and (1 S,2 S)-(+)-1,2-Diaminocyclohexane via 1H NMR Spectroscopy.

Authors:  Lei Feng; Guangpeng Gao; Hongmei Zhao; Li Zheng; Yu Wang; Pericles Stavropoulos; Lin Ai; Jiaxin Zhang
Journal:  J Org Chem       Date:  2018-10-30       Impact factor: 4.354

  1 in total

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