Literature DB >> 20544904

Synthesis of azaspirocycles and their evaluation in drug discovery.

Johannes A Burkhard1, Björn Wagner, Holger Fischer, Franz Schuler, Klaus Müller, Erick M Carreira.   

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Year:  2010        PMID： 20544904     DOI： 10.1002/anie.200907108

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  14 in total

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Journal:  Tetrahedron Lett       Date:  2016-12-23       Impact factor: 2.415

2.  Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores.

Authors:  Sean W Reilly; Suzy Griffin; Michelle Taylor; Kristoffer Sahlholm; Chi-Chang Weng; Kuiying Xu; Daniel A Jacome; Robert R Luedtke; Robert H Mach
Journal:  J Med Chem       Date:  2017-11-21       Impact factor: 7.446

3.  Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logD Lowering Twist.

Authors:  Sébastien L Degorce; Michael S Bodnarchuk; James S Scott
Journal:  ACS Med Chem Lett       Date:  2019-07-18       Impact factor: 4.345

4.  Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis.

Authors:  Maryne A J Dubois; Rosemary A Croft; Yujie Ding; Chulho Choi; Dafydd R Owen; James A Bull; James J Mousseau
Journal:  RSC Med Chem       Date:  2021-10-06

5.  Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

Authors:  Jason T Lowe; Maurice D Lee; Lakshmi B Akella; Emeline Davoine; Etienne J Donckele; Landon Durak; Jeremy R Duvall; Baudouin Gerard; Edward B Holson; Adrien Joliton; Sarathy Kesavan; Berenice C Lemercier; Haibo Liu; Jean-Charles Marié; Carol A Mulrooney; Giovanni Muncipinto; Morgan Welzel-O'Shea; Laura M Panko; Ann Rowley; Byung-Chul Suh; Meryl Thomas; Florence F Wagner; Jingqiang Wei; Michael A Foley; Lisa A Marcaurelle
Journal:  J Org Chem       Date:  2012-08-10       Impact factor: 4.354

6.  Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.

Authors:  Timothy R Hodges; Jason R Abbott; Andrew J Little; Dhruba Sarkar; James M Salovich; Jennifer E Howes; Denis T Akan; Jiqing Sai; Allison L Arnold; Carrie Browning; Michael C Burns; Tammy Sobolik; Qi Sun; Yugandhar Beesetty; Jesse A Coker; Dirk Scharn; Heinz Stadtmueller; Olivia W Rossanese; Jason Phan; Alex G Waterson; Darryl B McConnell; Stephen W Fesik
Journal:  J Med Chem       Date:  2018-09-28       Impact factor: 7.446

7.  Strain-Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones.

Authors:  Jasper L Tyler; Adam Noble; Varinder K Aggarwal
Journal:  Angew Chem Int Ed Engl       Date:  2021-04-16       Impact factor: 15.336

8.  Studies on the interaction of isocyanides with imines: reaction scope and mechanistic variations.

Authors:  Ouldouz Ghashghaei; Consiglia Annamaria Manna; Esther Vicente-García; Marc Revés; Rodolfo Lavilla
Journal:  Beilstein J Org Chem       Date:  2014-01-06       Impact factor: 2.883

9.  Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism.

Authors:  Tri Hv Huynh; Charles S Demmer; Bjarke Abrahamsen; Emil Marcher; Mikael Frykman; Anders A Jensen; Lennart Bunch
Journal:  Springerplus       Date:  2013-03-14

10.  Oxetanyl peptides: novel peptidomimetic modules for medicinal chemistry.

Authors:  Martin McLaughlin; Ryo Yazaki; Thomas C Fessard; Erick M Carreira
Journal:  Org Lett       Date:  2014-07-28       Impact factor: 6.005
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