Literature DB >> 20544531

How to use the computing environment R to analyze ATP-induced ribonucleotide reductase R1 hexamerization data.

T Radivoyevitch1.   

Abstract

R is an object oriented free and open source statistical computing environment. The R package Combinatorially Complex Equilibrium Model Selection is being developed to meet the analysis challenges of ribonucleotide reductase (RNR). An example of its use is given here. This example involves ATP-induced R1 hexamerization dynamic light scattering data that suggests that R1 hexamers have two types of a-sites, one that binds ATP and another that does not (here, R1 is the large subunit of RNR).

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Year:  2010        PMID: 20544531      PMCID: PMC2886286          DOI: 10.1080/15257771003741174

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  3 in total

Review 1.  Reduction of ribonucleotides.

Authors:  L Thelander; P Reichard
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

2.  A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit.

Authors:  Ossama B Kashlan; Charles P Scott; James D Lear; Barry S Cooperman
Journal:  Biochemistry       Date:  2002-01-15       Impact factor: 3.162

3.  Equilibrium model selection: dTTP induced R1 dimerization.

Authors:  Tomas Radivoyevitch
Journal:  BMC Syst Biol       Date:  2008-02-04
  3 in total

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