Literature DB >> 20544252

A case of metastatic testicular cancer complicated by pulmonary hemorrhage due to choriocarcinoma syndrome.

Shuya Kandori1, Koji Kawai, Yoshiharu Fukuhara, Akira Joraku, Naoto Miyanaga, Toru Shimazui, Hideyuki Akaza.   

Abstract

A 40-year-old man was referred to our hospital for treatment of metastatic testicular cancer. Computerized tomography revealed multiple lung, liver, and retroperitoneal lymph node metastases. In addition, magnetic resonance imaging revealed multiple brain metastases. Induction chemotherapy with bleomycin, etoposide, and cisplatin was started the day after a high orchiectomy. The pathological diagnosis of the surgical specimen was yolk sac carcinoma. The serum human chorionic gonadotropin (hCG) was markedly increased to 630,000 mIU/ml, which suggested the presence of a choriocarcinoma element at metastatic sites. The patient subsequently suffered respiratory failure due to pulmonary hemorrhage. Intensive supportive care prevented a fatal outcome. Physicians who treat advanced testicular tumors should be aware of the potential complication of acute pulmonary hemorrhage, called choriocarcinoma syndrome, in cases with a high hCG level, which indicates a rapidly progressive and high-volume choriocarcinoma.

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Year:  2010        PMID： 20544252     DOI： 10.1007/s10147-010-0092-3

Source DB:  PubMed          Journal:  Int J Clin Oncol        ISSN： 1341-9625            Impact factor:   3.402


  9 in total

1.  Randomized comparison of cisplatin and etoposide and either bleomycin or ifosfamide in treatment of advanced disseminated germ cell tumors: an Eastern Cooperative Oncology Group, Southwest Oncology Group, and Cancer and Leukemia Group B Study.

Authors:  C R Nichols; P J Catalano; E D Crawford; N J Vogelzang; L H Einhorn; P J Loehrer
Journal:  J Clin Oncol       Date:  1998-04       Impact factor: 44.544

2.  Irinotecan plus cisplatin has substantial antitumor effect as salvage chemotherapy against germ cell tumors.

Authors:  Tsuneharu Miki; Yoichi Mizutani; Norio Nonomura; Takeshi Nomoto; Masahiro Nakao; Shigeru Saiki; Toshihiko Kotake; Akihiko Okuyama
Journal:  Cancer       Date:  2002-11-01       Impact factor: 6.860

3.  Cyclic chemotherapy with cyclophosphamide, doxorubicin, and cisplatin plus vinblastine and bleomycin in advanced germinal tumors. Results with 100 patients.

Authors:  C J Logothetis; M L Samuels; D E Selig; S Ogden; F Dexeus; D Swanson; D Johnson; A von Eschenbach
Journal:  Am J Med       Date:  1986-08       Impact factor: 4.965

4.  Long-term results of first-line sequential high-dose carboplatin, etoposide and ifosfamide chemotherapy with peripheral blood stem cell support for patients with advanced testicular germ cell tumor.

Authors:  Tsuneharu Miki; Yoichi Mizutani; Hideyuki Akaza; Seiichiro Ozono; Taiji Tsukamoto; Toshiro Terachi; Katsusuke Naito; Norio Nonomura; Isao Hara; Osamu Yoshida
Journal:  Int J Urol       Date:  2007-01       Impact factor: 3.369

5.  Nonseminomatous germ cell tumor with very high serum human chorionic gonadotropin.

Authors:  J J McKendrick; J Theaker; G M Mead
Journal:  Cancer       Date:  1991-02-01       Impact factor: 6.860

6.  Hemorrhage: a complication of metastatic testicular choriocarcinoma.

Authors:  R J Motzer; G J Bosl
Journal:  Urology       Date:  1987-08       Impact factor: 2.649

7.  Acute respiratory distress syndrome after chemotherapy for lung metastases from non-seminomatous germ-cell tumors.

Authors:  C Kirch; F Blot; K Fizazi; B Raynard; C Theodore; G Nitenberg
Journal:  Support Care Cancer       Date:  2003-06-03       Impact factor: 3.603

8.  Successful management of life-threatening choriocarcinoma syndrome with rupture of pulmonary metastatic foci causing hemorrhagic shock.

Authors:  Manabu Tatokoro; Satoru Kawakami; Mizuaki Sakura; Tsuyoshi Kobayashi; Kazunori Kihara; Hideki Akamatsu
Journal:  Int J Urol       Date:  2008-03       Impact factor: 3.369

9.  Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide.

Authors:  S D Williams; R Birch; L H Einhorn; L Irwin; F A Greco; P J Loehrer
Journal:  N Engl J Med       Date:  1987-06-04       Impact factor: 91.245
  9 in total
  5 in total

1.  Choriocarcinoma syndrome in a 24-year-old male.

Authors:  Santiago Arana; Mariano Fielli; Alejandra González; Jaime Segovia; Marcelo Villaverde
Journal:  JRSM Short Rep       Date:  2012-06-28

Review 2.  A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature.

Authors:  Camille Keenan; Nicole Ramirez; Lucas Elijovich; Paul Klimo; Asim K Bag; Sahaja Acharya; Santhosh A Upadhyaya
Journal:  Pediatr Blood Cancer       Date:  2021-04-05       Impact factor: 3.838

3.  Choriocarcinoma Syndrome as an Initial Presentation of Testicular Cancer.

Authors:  Carlos Eduardo Salazar-Mejía; María Elena García-Gutiérrez; María Inés Contreras-Salcido; Carlos Javier Rodríguez-Álvarez; Blanca Otilia Wimer-Castillo; Jackeline Grace Lara-Campos; Edio Llerena-Hernández; José Luis González-Vela; David Hernández-Barajas
Journal:  Case Rep Oncol Med       Date:  2018-11-08

4.  Successful treatment of multisite hemorrhage by several methods in brain metastasis of choriocarcinoma: A case report.

Authors:  Zhen Ren; Li Yu; Mengnv Xie; Yiyi Liang; Fang Zhu; Rui Huang; Zhibang Zhang; Chun Fu
Journal:  Medicine (Baltimore)       Date:  2018-05       Impact factor: 1.889

5.  Testicular Germ Cell Tumors: Paraneoplastic Syndromes and the Role of Beta-Human Chorionic Gonadotropin.

Authors:  Toufic Tannous; John Miskovsky; Matthew Keating
Journal:  Cureus       Date:  2021-04-04
  5 in total

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