| Literature DB >> 20544107 |
Jinbo Gao1, Xiusheng Chu, Yongge Qiu, Long Wu, Yuqin Qiao, Jiasheng Wu, Ding Li.
Abstract
The mevalonate pathway is an important drug target for the treatment of cancer and cardiovascular disease. We synthesized and studied a new type of nitrogen-containing bisphosphonate analogs and developed a sensitive end point assay method for enzyme FPPS, which was used for inhibitor screening. One potent FPPS inhibitor was discovered, and the structure-activity relationship of bisphosphonates for the enzyme inactivation was studied.Entities:
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Year: 2010 PMID： 20544107 DOI： 10.1039/c0cc00992j
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222