Therapeutic implications of oxidative stress in acute and chronic pancreatitis.

PURPOSE OF REVIEW: This review presents new evidence on the role of oxidative stress and antioxidant status in acute and chronic pancreatitis published in the last year. RECENT
FINDINGS: In-vitro studies showed that protein phosphatases may play an important role in the interaction between reactive oxygen species and proinflammatory cytokines in acute pancreatitis. In-vivo studies found that several natural compounds ameliorate oxidative stress and, therefore, have therapeutic potential. In the domain of clinical studies, the major development is the first double-blind placebo-controlled randomized trial that showed effectiveness of oral antioxidant supplementation (organic selenium, ascorbic acid, alpha-tocopherol, beta-carotene, and methionine) in relieving pain in patients with chronic pancreatitis. The developments in clinical studies on acute pancreatitis are less spectacular and mainly limited to evaluation of different markers of oxidative stress and antioxidant status in the course of disease.
SUMMARY: A significant advance has been made in the arena of research in chronic, but not acute, pancreatitis. There is now solid evidence to justify the use of oral antioxidants in the treatment of patients with chronic pancreatitis. The progress in clinical research on antioxidants in acute pancreatitis is hampered by several factors, including suboptimal classification of acute pancreatitis and route of administration used in previous studies.