Literature DB >> 205430

Neuronal responses to extracellularly applied cyclic AMP:Role of the adenosine receptor.

D A Taylor, T W Stone.   

Abstract

At low doses, theophylline blocks the neuronal depressant effects of 5'-AMP, but not cyclic AMP. Higher doses (100 mg/kg) block cyclic AMP responses and reduce the effects of noradrenaline and GABA. It is concluded that cyclic AMP does not depress neurones via the adenosine receptor.

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Year:  1978        PMID： 205430     DOI： 10.1007/bf01935940

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

Review 1.  The role of cyclic nucleotides in central synaptic function.

Authors:  F E Bloom
Journal:  Rev Physiol Biochem Pharmacol       Date:  1975       Impact factor: 5.545

2.  Cyclic AMP and cyclic GMP may mediate opposite neuronal responses in the rat cerebral cortex.

Authors:  T W Stone; D A Taylor; F E Bloom
Journal:  Science       Date:  1975-03-07       Impact factor: 47.728

3.  Adenosine-dependent formation of cyclic AMP in brain slices.

Authors:  H D Mah; J W Daly
Journal:  Pharmacol Res Commun       Date:  1976-02

4.  The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies.

Authors:  M Segal; F E Bloom
Journal:  Brain Res       Date:  1974-05-31       Impact factor: 3.252

5.  The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

Authors:  A Sattin; T W Rall
Journal:  Mol Pharmacol       Date:  1970-01       Impact factor: 4.436

6.  Cyclic AMP mediation of norepinephrine inhibition in rat cerebellar cortex: a unique class of synaptic responses.

Authors:  B J Hoffer; G R Siggins; A P Oliver; F E Bloom
Journal:  Ann N Y Acad Sci       Date:  1971-12-30       Impact factor: 5.691

7.  Increase in the content of adenosine 3',5'-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines.

Authors:  A Sattin
Journal:  J Neurochem       Date:  1971-06       Impact factor: 5.372

8.  Depression of corticospinal cells by various purines and pyrimidines.

Authors:  J W Phillis; G K Kostopoulos; J J Limacher
Journal:  Can J Physiol Pharmacol       Date:  1974-12       Impact factor: 2.273

9.  Electrophysiology and cytology of hippocampal formation transplants in the anterior chamber of the eye. II. Cholinergic mechanisms.

Authors:  B Hoffer; A Seiger; R Freedman; L Olson; D Taylor
Journal:  Brain Res       Date:  1977-01-01       Impact factor: 3.252

10.  Microiontophoretic studies of the effects of cylic nucleotides on excitability of neurones in the rat cerebral cortex.

Authors:  T W Stone; D A Taylor
Journal:  J Physiol       Date:  1977-04       Impact factor: 5.182
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  6 in total

1.  Blockade of striatal neurone responses to morphine by aminophylline: evidence for adenosine mediation of opiate action.

Authors:  M N Perkins; T W Stone
Journal:  Br J Pharmacol       Date:  1980-05       Impact factor: 8.739

2.  Adenosine inhibition of gamma-aminobutyric acid release from slices of rat cerebral cortex.

Authors:  C Hollins; T W Stone
Journal:  Br J Pharmacol       Date:  1980-05       Impact factor: 8.739

3.  Adenine nucleotides and synaptic transmission in the in vitro rat hippocampus.

Authors:  T V Dunwiddie; B J Hoffer
Journal:  Br J Pharmacol       Date:  1980-05       Impact factor: 8.739

4.  Characteristics of the release of adenosine from slices of rat cerebral cortex.

Authors:  C Hollins; T W Stone
Journal:  J Physiol       Date:  1980-06       Impact factor: 5.182

5.  4-Aminopyridine blockade of neuronal depressant responses to adenosine triphosphate.

Authors:  M N Perkins; T W Stone
Journal:  Br J Pharmacol       Date:  1980-11       Impact factor: 8.739

6.  Antagonism by clonidine of neuronal depressant responses to adenosine, adenosine-5'-monophosphate and adenosine triphosphate.

Authors:  T W Stone; D A Taylor
Journal:  Br J Pharmacol       Date:  1978-11       Impact factor: 8.739
  6 in total

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