Literature DB >> 20541219

Renal podocyte apoptosis in Zucker diabetic fatty rats: involvement of methylglyoxal-induced oxidative DNA damage.

J Kim1, E Sohn, C-S Kim, J S Kim.   

Abstract

Methylglyoxal (MGO) is a cytotoxic metabolite produced by in-vivo glycolysis that may result in diabetic complications. The aim of this study was to determine whether MGO and oxidative stress caused apoptosis of renal podocytes in the Zucker diabetic fatty (ZDF) rat, an animal model of type 2 diabetes mellitus. Male ZDF rats aged 21 weeks developed marked hyperglycaemia with proteinuria and albuminuria. Immunohistochemical evaluation of sections of kidney demonstrated expression of MGO and 8-hydroxydeoxyguanosine (8-OHdG) in the podocytes of both normoglycaemic and diabetic rats. Podocyte apoptosis was shown through application of the TUNEL method. These findings suggest that expression of MGO and 8-OHdG is caused by hyperglycaemia, and that this expression is associated with the observed apoptosis of podocytes and is related to diabetic nephropathy.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20541219     DOI： 10.1016/j.jcpa.2010.04.008

Source DB:  PubMed          Journal:  J Comp Pathol        ISSN： 0021-9975            Impact factor:   1.311


  10 in total

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