Literature DB >> 20541127

Biosynthetic approach for the production of new aminoglycoside derivative.

Keshav Kumar Nepal1, Jin Cheol Yoo, Jae Kyung Sohng.   

Abstract

Aminoglycoside antibiotics can be classified into two major groups; streptamine containing and 2-deoxystreptamine containing antibiotics. Here, we report a biosynthetic approach for the fusion of spectinomycin and kanamycin biosynthetic gene clusters to yield the new aminoglycoside derivative, oxykanamycinC, in a non-aminoglycoside producing heterologous host. 2010 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID: 20541127     DOI: 10.1016/j.jbiosc.2010.01.005

Source DB:  PubMed          Journal:  J Biosci Bioeng        ISSN: 1347-4421            Impact factor:   2.894


  3 in total

Review 1.  Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis.

Authors:  Anthony J Romo; Hung-wen Liu
Journal:  Biochim Biophys Acta       Date:  2011-02-21

Review 2.  Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.

Authors:  Keshav K Nepal; Guojun Wang
Journal:  Biotechnol Adv       Date:  2018-10-09       Impact factor: 14.227

3.  Femtosecond laser-based mutagenesis strategy for micronomicin production enhancement of Micromonospora sagamiensis ATCC 21826.

Authors:  Peng Liu; Jianping Wen; Yunlin Chen; Xiaoqiang Jia
Journal:  World J Microbiol Biotechnol       Date:  2013-01-25       Impact factor: 3.312

  3 in total

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