| Literature DB >> 20538385 |
Sheng-Li Cao1, Yao Wang, Lin Zhu, Ji Liao, Yan-Wen Guo, Lin-Lin Chen, Hong-Qin Liu, Xingzhi Xu.
Abstract
A series of N-((2-methyl-4(3H)-quinazolinon-6-yl)methyl)dithiocarbamates 5a-w were synthesized and evaluated for their cytotoxic activity against five human cancer cell lines. We found that compound 5k inhibited proliferation of A549, MCF-7, HeLa, HT29 and HCT-116 cells with IC(50) values of 5.44, 7.15, 12.16, 10.35 and 11.44 microM, respectively. Compound 5i was the most potent with an IC(50) value of 3.65 microM against proliferation of MCF-7 cells, while 5n was the most potent with an IC(50) value of 5.09 microM against proliferation of A549 cells. Cell cycle analysis showed that both 5i and 5k arrested A549 cells at S and G2/M phases, suggesting that these compounds act through mechanisms different from 5-fluorouracil, which arrests cells at S phase only. 2010 Elsevier Masson SAS. All rights reserved.Entities:
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Year: 2010 PMID： 20538385 DOI： 10.1016/j.ejmech.2010.05.038
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514