OBJECTIVE: Effectiveness of preoperative and postoperative extracorporeal membrane oxygenation support in pediatric lung transplantation was studied. METHODS: Institutional database of pediatric lung transplants from 1990 to 2008 was reviewed. RESULTS: Three hundred forty-four patients underwent lung transplants in the study period. Thirty-three of 344 patients (9.6%) required perioperative extracorporeal membrane oxygenation support. Fifteen patients (median, age 1.3 years; range, 0.2-18 years) required 16 pretransplant extracorporeal membrane oxygenation runs. Indications were respiratory failure (8/16, 50%), severe pulmonary hypertension (5/16, 31%), and cardiopulmonary collapse (3/16, 19%). Four of these patients (27%) also required postoperative support. Six (40%) were weaned before lung transplant. Six (40%) survived to hospital discharge. Survival to discharge was higher among patients weaned before lung transplant (4/6, 66% vs 2/9, 22%). Twenty-two patients (median age, 9.4 years; range, 0.2-21 years) underwent 24 extracorporeal membrane oxygenation runs after lung transplant. Indications for postoperative support were primary graft dysfunction (18/24, 75%), pneumonia (4/24, 16%), and others (2/24, 9%). Median time between lung transplant and institution of extracorporeal membrane oxygenation was 32 hours (range, 0-1084 hours); median duration of support was 141 hours (range, 48-505 hours). Five of these patients (23%) survived to hospital discharge. Among nonsurvivors, causes of death were intractable respiratory failure (12/17, 70%) and infectious complications (4/17, 24%). CONCLUSIONS: Need for perioperative extracorporeal membrane oxygenation support is associated with significant morbidity and mortality among pediatric patients receiving lung transplants. A subset of patients who can be weaned from support preoperatively have greater likelihood of survival. Copyright 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
OBJECTIVE: Effectiveness of preoperative and postoperative extracorporeal membrane oxygenation support in pediatric lung transplantation was studied. METHODS: Institutional database of pediatric lung transplants from 1990 to 2008 was reviewed. RESULTS: Three hundred forty-four patients underwent lung transplants in the study period. Thirty-three of 344 patients (9.6%) required perioperative extracorporeal membrane oxygenation support. Fifteen patients (median, age 1.3 years; range, 0.2-18 years) required 16 pretransplant extracorporeal membrane oxygenation runs. Indications were respiratory failure (8/16, 50%), severe pulmonary hypertension (5/16, 31%), and cardiopulmonary collapse (3/16, 19%). Four of these patients (27%) also required postoperative support. Six (40%) were weaned before lung transplant. Six (40%) survived to hospital discharge. Survival to discharge was higher among patients weaned before lung transplant (4/6, 66% vs 2/9, 22%). Twenty-two patients (median age, 9.4 years; range, 0.2-21 years) underwent 24 extracorporeal membrane oxygenation runs after lung transplant. Indications for postoperative support were primary graft dysfunction (18/24, 75%), pneumonia (4/24, 16%), and others (2/24, 9%). Median time between lung transplant and institution of extracorporeal membrane oxygenation was 32 hours (range, 0-1084 hours); median duration of support was 141 hours (range, 48-505 hours). Five of these patients (23%) survived to hospital discharge. Among nonsurvivors, causes of death were intractable respiratory failure (12/17, 70%) and infectious complications (4/17, 24%). CONCLUSIONS: Need for perioperative extracorporeal membrane oxygenation support is associated with significant morbidity and mortality among pediatric patients receiving lung transplants. A subset of patients who can be weaned from support preoperatively have greater likelihood of survival. Copyright 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Authors: Fares Alghanem; Ryan P Davis; Benjamin S Bryner; Hayley R Hoffman; John Trahanas; Marie S Cornell; Alvaro Rojas-Peña; Robert H Bartlett; Ronald B Hirschl Journal: ASAIO J Date: 2015 Jul-Aug Impact factor: 2.872
Authors: David B Frank; Matthew A Crystal; David L S Morales; Ken Gerald; Brian D Hanna; George B Mallory; Joseph W Rossano Journal: Pulm Circ Date: 2015-06 Impact factor: 3.017
Authors: Kyle J Rehder; David A Turner; Matthew G Hartwig; W Lee Williford; Desiree Bonadonna; Richard J Walczak; R Duane Davis; David Zaas; Ira M Cheifetz Journal: Respir Care Date: 2012-12-04 Impact factor: 2.258
Authors: Fares Alghanem; Benjamin S Bryner; Emilia M Jahangir; Uditha P Fernando; John M Trahanas; Hayley R Hoffman; Robert H Bartlett; Alvaro Rojas-Peña; Ronald B Hirschl Journal: ASAIO J Date: 2017 Mar/Apr Impact factor: 2.872
Authors: Ryan A Orizondo; Alexandra G May; Shalv P Madhani; Brian J Frankowski; Greg W Burgreen; Peter D Wearden; William J Federspiel Journal: ASAIO J Date: 2018 Nov/Dec Impact factor: 2.872
Authors: Don Hayes; Mark Galantowicz; Thomas J Preston; Eric A Lloyd; Joseph D Tobias; Patrick I McConnell Journal: J Artif Organs Date: 2013-11-13 Impact factor: 1.731
Authors: Cecile Tissot; Walid Habre; Paola Soccal; Maja Isabel Hug; Dominique Bettex; Michel Pellegrini; Yacine Aggoun; Anne Mornand; Afksendyios Kalangos; Peter Rimensberger; Maurice Beghetti Journal: Res Cardiovasc Med Date: 2016-07-16
Authors: R Mark Grady; Matthew W Canter; Fei Wan; Anton A Shmalts; Ryan D Coleman; Maurice Beghetti; Rolf M F Berger; Maria J Del Cerro Marin; Scott E Fletcher; Russel Hirsch; Tilman Humpl; D Dunbar Ivy; Edward C Kirkpatrick; Thomas J Kulik; Marilyne Levy; Shahin Moledina; Delphine Yung; Pirooz Eghtesady; Damien Bonnet Journal: J Am Coll Cardiol Date: 2021-08-03 Impact factor: 27.203