Literature DB >> 20538267

Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells.

Eun Mi Choi1, Young Soon Lee.   

Abstract

This study was conducted to evaluate the efficacy of hesperetin in regulating interleukin-1beta (IL-1beta)-induced production of the matrix metalloproteinase (MMP)-3 and IL-6 in human synovial cell line, SW982. Treatment with hesperetin at 1 or 10 microM significantly (P<0.05) inhibited IL-1beta-induced MMP-3 and IL-6 production when measured by enzyme-linked immunosorbent assay (ELISA). The effects of hesperetin on the activation of mitogen-activated protein kinases (MAPKs) were also examined in SW982 cells by ELISA assay. IL-1beta-induced JNK activation was inhibited by hesperetin. These results suggest that hesperetin reduces the production of MMP and IL-6 in SW982 synovial cells by inhibiting JNK. 2010 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20538267     DOI： 10.1016/j.cellimm.2010.05.006

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  14 in total

1.  Dietary flavonoids and risk of stroke in women.

Authors:  Aedín Cassidy; Eric B Rimm; Eilis J O'Reilly; Giancarlo Logroscino; Colin Kay; Stephanie E Chiuve; Kathryn M Rexrode
Journal:  Stroke       Date:  2012-02-23       Impact factor: 7.914

Review 2.  Anti-inflammatory properties of orange juice: possible favorable molecular and metabolic effects.

Authors:  Raquel Cristina Lopes Assis Coelho; Helen Hermana M Hermsdorff; Josefina Bressan
Journal:  Plant Foods Hum Nutr       Date:  2013-03       Impact factor: 3.921

3.  Intravitreal kinetics of hesperidin, hesperetin, and hesperidin G: effect of dose and physicochemical properties.

Authors:  Ramesh Srirangam; Ketan Hippalgaonkar; Soumyajit Majumdar
Journal:  J Pharm Sci       Date:  2012-01-06       Impact factor: 3.534

4.  Hesperetin Suppresses Inflammatory Responses in Lipopolysaccharide-Induced RAW 264.7 Cells via the Inhibition of NF-κB and Activation of Nrf2/HO-1 Pathways.

Authors:  Hua Ren; Jilong Hao; Taotao Liu; Dongyan Zhang; Hongming Lv; E Song; Chao Zhu
Journal:  Inflammation       Date:  2016-06       Impact factor: 4.092

5.  Evaluation of the intravenous and topical routes for ocular delivery of hesperidin and hesperetin.

Authors:  Ramesh Srirangam; Ketan Hippalgaonkar; Bharathi Avula; Ikhlas A Khan; Soumyajit Majumdar
Journal:  J Ocul Pharmacol Ther       Date:  2012-07-13       Impact factor: 2.671

Review 6.  Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2.

Authors:  Abhishek Gour; Diksha Manhas; Swarnendu Bag; Bapi Gorain; Utpal Nandi
Journal:  Phytother Res       Date:  2021-03-30       Impact factor: 6.388

Review 7.  Effects of Citrus Fruit Juices and Their Bioactive Components on Inflammation and Immunity: A Narrative Review.

Authors:  Elizabeth A Miles; Philip C Calder
Journal:  Front Immunol       Date:  2021-06-24       Impact factor: 7.561

8.  100% Fruit juice intake and cardiovascular risk: a systematic review and meta-analysis of prospective and randomised controlled studies.

Authors:  Lanfranco D'Elia; Monica Dinu; Francesco Sofi; Massimo Volpe; Pasquale Strazzullo
Journal:  Eur J Nutr       Date:  2020-11-04       Impact factor: 5.614

9.  Caenorhabditis elegans as model system in pharmacology and toxicology: effects of flavonoids on redox-sensitive signalling pathways and ageing.

Authors:  Karoline Koch; Susannah Havermann; Christian Büchter; Wim Wätjen
Journal:  ScientificWorldJournal       Date:  2014-04-30

10.  Investigation of the cytokine response to NF-κB decoy oligonucleotide coated polysaccharide based nanoparticles in rheumatoid arthritis in vitro models.

Authors:  Patricia R Wardwell; Martin B Forstner; Rebecca A Bader
Journal:  Arthritis Res Ther       Date:  2015-11-04       Impact factor: 5.156
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.