Literature DB >> 20538072

Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.

Paul A Dawson1, Melissa L Hubbert, Anuradha Rao.   

Abstract

The organic solute transporter (OST)(alpha)-OST(beta) is an unusual heteromeric carrier expressed in a variety of tissues including the small intestine, colon, liver, biliary tract, kidney, and adrenal gland. In polarized epithelial cells, OSTalpha-OSTbeta protein is localized on the basolateral membrane and functions in the export or uptake of bile acids and steroids. This article reviews recent results including studies of knockout mouse models that provide new insights to the role of OSTalpha-OSTbeta in the compartmentalization and metabolism of these important lipids. 2010 Elsevier B.V. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20538072      PMCID： PMC2911127          DOI： 10.1016/j.bbalip.2010.06.002

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  109 in total

1.  Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.

Authors:  Hiroshi Kurosu; Mihwa Choi; Yasushi Ogawa; Addie S Dickson; Regina Goetz; Anna V Eliseenkova; Moosa Mohammadi; Kevin P Rosenblatt; Steven A Kliewer; Makoto Kuro-o
Journal:  J Biol Chem       Date:  2007-07-10       Impact factor: 5.157

2.  The farnesoid X receptor regulates transcription of 3beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells.

Authors:  Yewei Xing; Karla Saner-Amigh; Yasuhiro Nakamura; Margaret M Hinshelwood; Bruce R Carr; J Ian Mason; William E Rainey
Journal:  Mol Cell Endocrinol       Date:  2008-11-18       Impact factor: 4.102

3.  GATA4 is essential for jejunal function in mice.

Authors:  Michele A Battle; Benjamin J Bondow; Moriah A Iverson; Scott J Adams; Ronald J Jandacek; Patrick Tso; Stephen A Duncan
Journal:  Gastroenterology       Date:  2008-08-03       Impact factor: 22.682

4.  High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis.

Authors:  Frank G Schaap; Niels A van der Gaag; Dirk J Gouma; Peter L M Jansen
Journal:  Hepatology       Date:  2009-04       Impact factor: 17.425

Review 5.  Targeting bile-acid signalling for metabolic diseases.

Authors:  Charles Thomas; Roberto Pellicciari; Mark Pruzanski; Johan Auwerx; Kristina Schoonjans
Journal:  Nat Rev Drug Discov       Date:  2008-08       Impact factor: 84.694

Review 6.  Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics.

Authors:  A F Hofmann; L R Hagey
Journal:  Cell Mol Life Sci       Date:  2008-08       Impact factor: 9.261

7.  Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease.

Authors:  Olga Renner; Simone Harsch; André Strohmeyer; Silke Schimmel; Eduard F Stange
Journal:  J Lipid Res       Date:  2008-05-09       Impact factor: 5.922

Review 8.  OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.

Authors:  Nazzareno Ballatori; Na Li; Fang Fang; James L Boyer; Whitney V Christian; Christine L Hammond
Journal:  Front Biosci (Landmark Ed)       Date:  2009-01-01

9.  N-Glycosylation of the alpha subunit does not influence trafficking or functional activity of the human organic solute transporter alpha/beta.

Authors:  Carol J Soroka; Shuhua Xu; Albert Mennone; Ping Lam; James L Boyer
Journal:  BMC Cell Biol       Date:  2008-10-10       Impact factor: 4.241

10.  Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.

Authors:  Simone M R Camargo; Dustin Singer; Victoria Makrides; Katja Huggel; Klaas M Pos; Carsten A Wagner; Keiji Kuba; Ursula Danilczyk; Flemming Skovby; Robert Kleta; Josef M Penninger; François Verrey
Journal:  Gastroenterology       Date:  2008-10-29       Impact factor: 22.682
View more
  34 in total

1.  Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.

Authors:  Sadie G Wheeler; Christine L Hammond; François R Jornayvaz; Varman T Samuel; Gerald I Shulman; Carol J Soroka; James L Boyer; Patricia M Hinkle; Nazzareno Ballatori
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2013-12-31       Impact factor: 4.052

2.  Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis.

Authors:  Nevzat Kazgan; Mallikarjuna R Metukuri; Aparna Purushotham; Jing Lu; Anuradha Rao; Sangkyu Lee; Matthew Pratt-Hyatt; Andrew Lickteig; Iván L Csanaky; Yingming Zhao; Paul A Dawson; Xiaoling Li
Journal:  Gastroenterology       Date:  2013-12-31       Impact factor: 22.682

3.  Role of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions.

Authors:  James J Beaudoin; Jacqueline Bezençon; Noora Sjöstedt; John K Fallon; Kim L R Brouwer
Journal:  Toxicol Sci       Date:  2020-07-01       Impact factor: 4.849

4.  Human Organic Solute Transporter (hOST): protein interaction and membrane sorting process.

Authors:  An-Qiang Sun; Libin Zhu; Yuhuan Luo; Shuhua Xu; Jing Lin; Frederick J Suchy
Journal:  Int J Biochem Mol Biol       Date:  2012-09-25

Review 5.  Bile acids are nutrient signaling hormones.

Authors:  Huiping Zhou; Phillip B Hylemon
Journal:  Steroids       Date:  2014-05-10       Impact factor: 2.668

Review 6.  Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside.

Authors:  James J Beaudoin; Kim L R Brouwer; Melina M Malinen
Journal:  Pharmacol Ther       Date:  2020-04-02       Impact factor: 12.310

7.  Transmembrane protein OSTA-1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans.

Authors:  Anique Olivier-Mason; Martin Wojtyniak; Rachel V Bowie; Inna V Nechipurenko; Oliver E Blacque; Piali Sengupta
Journal:  Development       Date:  2013-04       Impact factor: 6.868

Review 8.  Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters.

Authors:  M Sawkat Anwer; Bruno Stieger
Journal:  Pflugers Arch       Date:  2013-10-03       Impact factor: 3.657

Review 9.  Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease.

Authors:  Douglas G Burrin; Ken Ng; Barbara Stoll; Miguel Sáenz De Pipaón
Journal:  Adv Nutr       Date:  2014-01-01       Impact factor: 8.701

Review 10.  Pleiotropic roles of bile acids in metabolism.

Authors:  Thomas Q de Aguiar Vallim; Elizabeth J Tarling; Peter A Edwards
Journal:  Cell Metab       Date:  2013-04-18       Impact factor: 27.287
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.