| Literature DB >> 20537965 |
John Le Quesne1, Carlos Caldas.
Abstract
Micro-RNAs (miRs) are a recently described class of genes, encoding small non-coding RNA molecules, which primarily act by down-regulating the translation of target mRNAs. miRs are involved in a range of normal physiological processes, notably differentiation and cell type determination. It has become apparent that they are also key factors in cancer, playing both oncogenic and tumour-suppressing roles. We discuss here what is known of miR biology in the normal breast, and of their emerging roles in breast cancer. (c) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID: 20537965 PMCID: PMC5527936 DOI: 10.1016/j.molonc.2010.04.009
Source DB: PubMed Journal: Mol Oncol ISSN: 1574-7891 Impact factor: 6.603