Literature DB >> 20535423

Effectiveness of vacuum-assisted closure (VAC) therapy in the healing of chronic diabetic foot ulcers.

Aziz Nather1, Siok Bee Chionh, Audrey Y Y Han, Pauline P L Chan, Ajay Nambiar.   

Abstract

INTRODUCTION: This is the fi rst prospective study done locally to determine the effectiveness of vacuum-assisted closure (VAC) therapy in the healing of chronic diabetic foot ulcers.
MATERIALS AND METHODS: An electronic vacuum pump was used to apply controlled negative pressure evenly across the wound surface. Changes in wound dimension, presence of wound granulation and infection status of diabetic foot ulcers in 11 consecutive patients with diabetes were followed over the course of VAC therapy.
RESULTS: Healing was achieved in all wounds. Nine wounds were closed by split-skin grafting and 2 by secondary closure. The average length of treatment with VAC therapy was 23.3 days. Ten wounds showed reduction in wound size. All wounds were satisfactorily granulated and cleared of bacterial infection at the end of VAC therapy.
CONCLUSIONS: VAC therapy was useful in the treatment of diabetic foot infection and ulcers, which after debridement, may present with exposed tendon, fascia and/or bone. These included ray amputation wounds, wounds post-debridement for necrotising fasciitis, wounds post-drainage for abscess, a heel ulcer and a sole ulcer. It was able to prepare ulcers well for closure via split-skin grafting or secondary closure in good time. This reduced cost of VAC therapy, as therapy was not prolonged to attain greater reduction in wound area. VAC therapy also provides a sterile, more controlled resting environment to large, exudating wound surfaces. Large diabetic foot ulcers were thus made more manageable.

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Year:  2010        PMID: 20535423

Source DB:  PubMed          Journal:  Ann Acad Med Singap        ISSN: 0304-4602            Impact factor:   2.473


  16 in total

1.  Combined use of super-oxidised solution with negative pressure for the treatment of pressure ulcers: case report.

Authors:  Barbara de Angelis; Lucilla Lucarini; Annarita Agovino; Alessia Migner; Fabrizio Orlandi; Micol Floris; Valerio Cervelli; Cristiano Curcio
Journal:  Int Wound J       Date:  2012-05-24       Impact factor: 3.315

Review 2.  Management of negative pressure wound therapy in the treatment of diabetic foot ulcers.

Authors:  Marco Meloni; Valentina Izzo; Erika Vainieri; Laura Giurato; Valeria Ruotolo; Luigi Uccioli
Journal:  World J Orthop       Date:  2015-05-18

3.  VAC therapy to promote wound healing after surgical revascularisation for critical lower limb ischaemia.

Authors:  Giovanni De Caridi; Mafalda Massara; Michele Greco; Narayana Pipitò; Francesco Spinelli; Raffaele Grande; Lucia Butrico; Stefano de Franciscis; Raffaele Serra
Journal:  Int Wound J       Date:  2014-05-28       Impact factor: 3.315

Review 4.  Slow to heel: a literature review on the management of diabetic calcaneal ulceration.

Authors:  Rachel Khoo; Shirley Jansen
Journal:  Int Wound J       Date:  2018-02-12       Impact factor: 3.315

5.  [Local fixation of antibiotics by fibrin spray : In bone defects with soft tissue involvement].

Authors:  Maren Janko; Christoph Nau; Ingo Marzi; Johannes Frank
Journal:  Chirurg       Date:  2017-02       Impact factor: 0.955

Review 6.  Emerging drugs for the treatment of diabetic ulcers.

Authors:  Francesco Tecilazich; Thanh L Dinh; Aristidis Veves
Journal:  Expert Opin Emerg Drugs       Date:  2013-05-21       Impact factor: 4.191

7.  Diabetic foot infection treatment and care.

Authors:  Emanuele Cigna; Pasquale Fino; Maria G Onesti; Vittoria Amorosi; Nicolò Scuderi
Journal:  Int Wound J       Date:  2014-04-14       Impact factor: 3.315

8.  Role of negative pressure wound therapy in healing of diabetic foot ulcers.

Authors:  Aziz Nather
Journal:  J Surg Tech Case Rep       Date:  2011-01

9.  Effectiveness of bridge V.A.C. dressings in the treatment of diabetic foot ulcers.

Authors:  Aziz Nather; Ng Yau Hong; Wong Keng Lin; Joshi Abhijit Sakharam
Journal:  Diabet Foot Ankle       Date:  2011-03-04

10.  Efficacy and safety of IV/PO moxifloxacin and IV piperacillin/tazobactam followed by PO amoxicillin/clavulanic acid in the treatment of diabetic foot infections: results of the RELIEF study.

Authors:  N C Schaper; M Dryden; P Kujath; D Nathwani; P Arvis; P Reimnitz; J Alder; I C Gyssens
Journal:  Infection       Date:  2012-11-23       Impact factor: 3.553

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