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Literature DB >> 20534341

DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.

Yves Pommier¹, Elisabetta Leo, HongLiang Zhang, Christophe Marchand.

Abstract

DNA topoisomerases are the targets of important anticancer and antibacterial drugs. Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines and ARC-111) target eukaryotic type IB topoisomerases (Top1), whereas human type IIA topoisomerases (Top2alpha and Top2beta) are the targets of the widely used anticancer agents etoposide, anthracyclines (doxorubicin, daunorubicin), and mitoxantrone. Bacterial type II topoisomerases (gyrase and Topo IV) are the targets of quinolones and aminocoumarin antibiotics. This review focuses on the molecular and biochemical characteristics of topoisomerases and their inhibitors. We also discuss the common mechanism of action of topoisomerase poisons by interfacial inhibition and trapping of topoisomerase cleavage complexes. 2010 Elsevier Ltd. All rights reserved.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2010 PMID： 20534341 PMCID： PMC7316379 DOI： 10.1016/j.chembiol.2010.04.012

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

120 in total

Review 1. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice.

Authors: J M Fortune; N Osheroff
Journal: Prog Nucleic Acid Res Mol Biol Date: 2000

2. A truncated form of DNA topoisomerase IIbeta associates with the mtDNA genome in mammalian mitochondria.

Authors: Robert L Low; Shayla Orton; David B Friedman
Journal: Eur J Biochem Date: 2003-10

Review 3. New inhibitors of bacterial topoisomerase GyrA/ParC subunits.

Authors: Michael T Black; Kenneth Coleman
Journal: Curr Opin Investig Drugs Date: 2009-08

Review 4. DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.

Authors: Allyn J Schoeffler; James M Berger
Journal: Q Rev Biophys Date: 2008-02 Impact factor: 5.318

5. Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks.

Authors: A Kathleen McClendon; A Chapin Rodriguez; Neil Osheroff
Journal: J Biol Chem Date: 2005-09-27 Impact factor: 5.157

Review 6. Topoisomerase I inhibitors: camptothecins and beyond.

Authors: Yves Pommier
Journal: Nat Rev Cancer Date: 2006-10 Impact factor: 60.716

7. Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.

Authors: Jens Pedersen-Bjergaard; Mette K Andersen; Debes H Christiansen; Claus Nerlov
Journal: Blood Date: 2002-03-15 Impact factor: 22.113

8. Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.

Authors: H Yoshida; M Bogaki; M Nakamura; L M Yamanaka; S Nakamura
Journal: Antimicrob Agents Chemother Date: 1991-08 Impact factor: 5.191

9. Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants.

Authors: Supaart Sirikantaramas; Mami Yamazaki; Kazuki Saito
Journal: Proc Natl Acad Sci U S A Date: 2008-04-28 Impact factor: 11.205

10. Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.

Authors: Kazutaka Takagi; Thomas S Dexheimer; Christophe Redon; Olivier Sordet; Keli Agama; Gilbert Lavielle; Alain Pierré; Susan E Bates; Yves Pommier
Journal: Mol Cancer Ther Date: 2007-12 Impact factor: 6.261

570 in total

1. Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide.

Authors: Hong Zhao; Paulina Rybak; Jurek Dobrucki; Frank Traganos; Zbigniew Darzynkiewicz
Journal: Cytometry A Date: 2011-12-02 Impact factor: 4.355

2. High salt and DNA double-strand breaks.

Authors: Christophe E Redon; William M Bonner
Journal: Proc Natl Acad Sci U S A Date: 2011-12-12 Impact factor: 11.205

3. Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.

Authors: Junko Murai; Shar-yin N Huang; Benu Brata Das; Thomas S Dexheimer; Shunichi Takeda; Yves Pommier
Journal: J Biol Chem Date: 2012-02-27 Impact factor: 5.157

4. DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity.

Authors: P Fortini; C Ferretti; B Pascucci; L Narciso; D Pajalunga; E M R Puggioni; R Castino; C Isidoro; M Crescenzi; E Dogliotti
Journal: Cell Death Differ Date: 2012-06-15 Impact factor: 15.828

5. Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors.

Authors: Stéphanie Solier; Jennifer Barb; Barry R Zeeberg; Sudhir Varma; Mike C Ryan; Kurt W Kohn; John N Weinstein; Peter J Munson; Yves Pommier
Journal: Cancer Res Date: 2010-09-03 Impact factor: 12.701

6. Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells.

Authors: Zhen-yu Shi; Yong-qiang Li; Yu-hua Kang; Guo-qiang Hu; Chao-shen Huang-fu; Jin-Bo Deng; Bin Liu
Journal: Acta Pharmacol Sin Date: 2012-02 Impact factor: 6.150

7. Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.

Authors: Adam C Ketron; William A Denny; David E Graves; Neil Osheroff
Journal: Biochemistry Date: 2012-02-10 Impact factor: 3.162

8. Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors.

Authors: Sai-Wen Tang; Anish Thomas; Junko Murai; Jane B Trepel; Susan E Bates; Vinodh N Rajapakse; Yves Pommier
Journal: Clin Cancer Res Date: 2018-02-01 Impact factor: 12.531

9. Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance.

Authors: Devon M Fitzgerald; P J Hastings; Susan M Rosenberg
Journal: Annu Rev Cancer Biol Date: 2017-03

10. Biological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.

Authors: Neil R Stokes; Helena B Thomaides-Brears; Stephanie Barker; James M Bennett; Joanne Berry; Ian Collins; Lloyd G Czaplewski; Vicki Gamble; Paul Lancett; Alastair Logan; Christopher J Lunniss; Hilary Peasley; Stéphanie Pommier; Daniel Price; Carol Smee; David J Haydon
Journal: Antimicrob Agents Chemother Date: 2013-09-16 Impact factor: 5.191