BACKGROUND: In most cases of renal cell carcinoma there is no family history of renal cancer and no hereditary cause of the disease. Hereditary renal cancer accounts for about 2-4% of cases. Recognition of this subgroup by clinicians is important because of the possibility of severe medical consequences for patients and their relatives. MATERIALS AND METHODS: We review the latest data about different genetic conditions characterized by an increased risk of developing renal cancer and we formulate tools to recognize high-risk families. RESULTS: In general, a positive family history, young age at diagnosis of renal cancer, multiple and/or bilateral renal tumours and combined occurrence of different histological types of renal tumours should raise suspicion of a hereditary renal tumour syndrome. In addition, the presence of specific extrarenal symptoms in patients could assist in differentiating between tumour syndromes. CONCLUSIONS: A detailed medical and family history, along with physical examination are key factors to diagnose hereditary renal cancer syndromes. When a genetic predisposition for renal cancer is suspected, referral to a Family Cancer Clinic is warranted to initiate genetic examination and counselling on preventive options.
BACKGROUND: In most cases of renal cell carcinoma there is no family history of renal cancer and no hereditary cause of the disease. Hereditary renal cancer accounts for about 2-4% of cases. Recognition of this subgroup by clinicians is important because of the possibility of severe medical consequences for patients and their relatives. MATERIALS AND METHODS: We review the latest data about different genetic conditions characterized by an increased risk of developing renal cancer and we formulate tools to recognize high-risk families. RESULTS: In general, a positive family history, young age at diagnosis of renal cancer, multiple and/or bilateral renal tumours and combined occurrence of different histological types of renal tumours should raise suspicion of a hereditary renal tumour syndrome. In addition, the presence of specific extrarenal symptoms in patients could assist in differentiating between tumour syndromes. CONCLUSIONS: A detailed medical and family history, along with physical examination are key factors to diagnose hereditary renal cancer syndromes. When a genetic predisposition for renal cancer is suspected, referral to a Family Cancer Clinic is warranted to initiate genetic examination and counselling on preventive options.
Authors: M Neil Reaume; Gail E Graham; Eva Tomiak; Suzanne Kamel-Reid; Michael A S Jewett; Georg A Bjarnason; Normand Blais; Melanie Care; Darryl Drachenberg; Craig Gedye; Ronald Grant; Daniel Y C Heng; Anil Kapoor; Christian Kollmannsberger; Jean-Baptiste Lattouf; Eamonn R Maher; Arnim Pause; Dean Ruether; Denis Soulieres; Simon Tanguay; Sandra Turcotte; Philippe D Violette; Lori Wood; Joan Basiuk; Stephen E Pautler Journal: Can Urol Assoc J Date: 2013 Sep-Oct Impact factor: 1.862
Authors: Maria Bejerholm Christensen; Karin Wadt; Uffe Birk Jensen; Charlotte Kvist Lautrup; Anders Bojesen; Lotte Nylandsted Krogh; Thomas van Overeem Hansen; Anne-Marie Gerdes Journal: PLoS One Date: 2019-04-29 Impact factor: 3.240