Literature DB >> 20532153

Treatment of fibromyalgia.

Peter Dussias1, Amir H Kalali, Roland M Staud.   

Abstract

In this article, we investigate the range of treatments prescribed for fibromyalgia. The data suggest that the majority of those treated, 82 percent, receive only one pharmaceutical. An additional 12 percent of patients were prescribed two products and six percent received three products. Pregabalin (Lyrica(R)) monotherapy was the most commonly prescribed regimen (21% of patients) followed by duloxetine (Cymbalta(R)) monotherapy (20%). From a therapeutic class perspective, fibromyalgia patients received antidepressants (46%), antiepileptics (35%), pain therapies (25%), muscle relaxants (8%), and sleep agents (2%). An expert commentary is included.

Entities:  

Keywords:  duloxetine; fibromyalgia; gabapentin; milnacipran; pharmacology; pregabalin

Year:  2010        PMID: 20532153      PMCID: PMC2882278     

Source DB:  PubMed          Journal:  Psychiatry (Edgmont)        ISSN: 1550-5952


  7 in total

Review 1.  Anticonvulsants in neuropathic pain: rationale and clinical evidence.

Authors:  Troels S Jensen
Journal:  Eur J Pain       Date:  2002       Impact factor: 3.931

2.  Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia.

Authors:  Samuel A McLean; David A Williams; Richard E Harris; Willem J Kop; Kimberly H Groner; Kirsten Ambrose; Angela K Lyden; Richard H Gracely; Leslie J Crofford; Michael E Geisser; Ananda Sen; Pinaki Biswas; Daniel J Clauw
Journal:  Arthritis Rheum       Date:  2005-11

Review 3.  Neuroendocrine perturbations in fibromyalgia and chronic fatigue syndrome.

Authors:  G Neeck; L J Crofford
Journal:  Rheum Dis Clin North Am       Date:  2000-11       Impact factor: 2.670

4.  Treatment of fibromyalgia syndrome with antidepressants: a meta-analysis.

Authors:  Winfried Häuser; Kathrin Bernardy; Nurcan Uçeyler; Claudia Sommer
Journal:  JAMA       Date:  2009-01-14       Impact factor: 56.272

5.  A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder.

Authors:  Lesley M Arnold; Yili Lu; Leslie J Crofford; Madelaine Wohlreich; Michael J Detke; Smriti Iyengar; David J Goldstein
Journal:  Arthritis Rheum       Date:  2004-09

6.  Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study.

Authors:  Roland Staud; Susann Nagel; Michael E Robinson; Donald D Price
Journal:  Pain       Date:  2009-06-21       Impact factor: 6.961

7.  Pharmacological treatment of fibromyalgia syndrome: new developments.

Authors:  Roland Staud
Journal:  Drugs       Date:  2010       Impact factor: 9.546

  7 in total

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