Literature DB >> 20531986

It's a knockout: CCN3 suppresses neointimal thickening.

Andrew Leask1.   

Abstract

The role of CCN proteins in vivo is only just becoming understood. A prototypical member of the CCN family, CCN3 suppresses proliferation. In a study in press, Shimoyama and colleagues show that mice lacking CCN3 have a hyperproliferative response to vascular injury. These data, along with other recent observations, suggest that CCN3 may represent a novel therapy for hyperproliferative diseases.

Entities:  

Keywords:  CCN3; Hyperplasia; Injury; Nov; Vasculature

Year:  2010        PMID： 20531986      PMCID： PMC2876238          DOI： 10.1007/s12079-010-0086-y

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  12 in total

Review 1.  All in the CCN family: essential matricellular signaling modulators emerge from the bunker.

Authors:  Andrew Leask; David J Abraham
Journal:  J Cell Sci       Date:  2006-12-01       Impact factor: 5.285

2.  CCN3: Doctor Jekyll and Mister Hyde.

Authors:  Bernard Perbal
Journal:  J Cell Commun Signal       Date:  2008-09-12       Impact factor: 5.782

3.  CCN3: A novel function in vivo.

Authors:  Andrew Leask
Journal:  J Cell Commun Signal       Date:  2008-05-28       Impact factor: 5.782

4.  CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration.

Authors:  Tatsushi Shimoyama; Shûichi Hiraoka; Minoru Takemoto; Masaya Koshizaka; Hirotake Tokuyama; Takahiko Tokuyama; Aki Watanabe; Masaki Fujimoto; Harukiyo Kawamura; Seiya Sato; Yuya Tsurutani; Yasushi Saito; Bernard Perbal; Haruhiko Koseki; Koutaro Yokote
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-02-05       Impact factor: 8.311

5.  Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development.

Authors:  Sanja Ivkovic; Byeong S Yoon; Steven N Popoff; Fayez F Safadi; Diana E Libuda; Robert C Stephenson; Aaron Daluiski; Karen M Lyons
Journal:  Development       Date:  2003-06       Impact factor: 6.868

6.  CCN3 (NOV) is a negative regulator of CCN2 (CTGF) and a novel endogenous inhibitor of the fibrotic pathway in an in vitro model of renal disease.

Authors:  Bruce L Riser; Feridoon Najmabadi; Bernard Perbal; Darryl R Peterson; Jo Ann Rambow; Melisa L Riser; Ernest Sukowski; Herman Yeger; Sarah C Riser
Journal:  Am J Pathol       Date:  2009-04-09       Impact factor: 4.307

7.  CYR61 (CCN1) is essential for placental development and vascular integrity.

Authors:  Fan-E Mo; Andrew G Muntean; Chih-Chiun Chen; Donna B Stolz; Simon C Watkins; Lester F Lau
Journal:  Mol Cell Biol       Date:  2002-12       Impact factor: 4.272

8.  Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage.

Authors:  Harumi Kawaki; Satoshi Kubota; Akiko Suzuki; Noureddine Lazar; Tomohiro Yamada; Tatsushi Matsumura; Toshihiro Ohgawara; Takeyasu Maeda; Bernard Perbal; Karen M Lyons; Masaharu Takigawa
Journal:  J Bone Miner Res       Date:  2008-11       Impact factor: 6.741

9.  Yin and Yang: CCN3 inhibits the pro-fibrotic effects of CCN2.

Authors:  Andrew Leask
Journal:  J Cell Commun Signal       Date:  2009-05-29       Impact factor: 5.782

10.  Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene.

Authors:  Emma Heath; Dalal Tahri; Elisabetta Andermarcher; Paul Schofield; Stewart Fleming; Catherine A Boulter
Journal:  BMC Dev Biol       Date:  2008-02-20       Impact factor: 1.978
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  2 in total

1.  Editorial for Issue 1, Jan 2016 title of the editorial 2016 : A year for JCCS Editorial changes and CCN3 KO mice at ICCNS.

Authors:  Bernard Perbal
Journal:  J Cell Commun Signal       Date:  2016-02-23       Impact factor: 5.782

2.  Periostin is required for matricellular localization of CCN3 in periodontal ligament of mice.

Authors:  Issei Takayama; Hideyuki Tanabe; Takashi Nishiyama; Harumi Ito; Norio Amizuka; Minqi Li; Ken-Ichi Katsube; Isao Kii; Akira Kudo
Journal:  J Cell Commun Signal       Date:  2016-12-24       Impact factor: 5.782
  2 in total

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