Literature DB >> 20531982

Role of prostaglandins in fibroblast activation and fibrosis.

Richard Stratton1, Xu Shiwen.   

Abstract

Fibroblasts release prostaglandins and express a range of prostanoid receptors. However the importance of prostaglandins in fibroblast biology have not been fully explored. Our studies showed that the prostaglandin metabolite PGI(2) blocks the activation of fibroblasts, antagonising the induction of Ras/MEK/ERK signalling by TGFbeta. Endogenous PGI(2) acts so as to limit the activation of fibroblasts following tissue injury. By contrast PGE(2) induced in injured tissues or disease states may promote recruitment of inflammatory cells and lead to secondary activation of fibroblasts. The effects of PGI(2) on cell signaling could be manipulated to inhibit fibrosis in patients.

Entities:  

Keywords:  Fibrosis; Inflammation; Prostacyclin; Prostaglandin; Tissue repair

Year:  2010        PMID： 20531982      PMCID： PMC2876240          DOI： 10.1007/s12079-010-0089-8

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  17 in total

1.  Prostacyclin protects against elevated blood pressure and cardiac fibrosis.

Authors:  Helene Francois; Krairerk Athirakul; David Howell; Rajesh Dash; Lan Mao; Hyung-Suk Kim; Howard A Rockman; Garret A Fitzgerald; Beverly H Koller; Thomas M Coffman
Journal:  Cell Metab       Date:  2005-09       Impact factor: 27.287

Review 2.  Function of prostanoid receptors: studies on knockout mice.

Authors:  Takuya Kobayashi; Shuh Narumiya
Journal:  Prostaglandins Other Lipid Mediat       Date:  2002-08       Impact factor: 3.072

3.  Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients.

Authors:  R Stratton; X Shiwen; G Martini; A Holmes; A Leask; T Haberberger; G R Martin; C M Black; D Abraham
Journal:  J Clin Invest       Date:  2001-07       Impact factor: 14.808

4.  Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis.

Authors:  T Tanioka; Y Nakatani; N Semmyo; M Murakami; I Kudo
Journal:  J Biol Chem       Date:  2000-10-20       Impact factor: 5.157

5.  Identification and characterization of a novel type of membrane-associated prostaglandin E synthase.

Authors:  Naomi Tanikawa; Yoshihiro Ohmiya; Hiroaki Ohkubo; Katsuyuki Hashimoto; Kenji Kangawa; Masami Kojima; Seiji Ito; Kikuko Watanabe
Journal:  Biochem Biophys Res Commun       Date:  2002-03-08       Impact factor: 3.575

6.  Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.

Authors:  P J Jakobsson; S Thorén; R Morgenstern; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

7.  Regulation of connective tissue growth factor expression by prostaglandin E(2).

Authors:  D A Ricupero; D C Rishikof; P P Kuang; C F Poliks; R H Goldstein
Journal:  Am J Physiol       Date:  1999-12

8.  Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis.

Authors:  Derek W Gilroy; Paul R Colville-Nash; Shaun McMaster; Deborah A Sawatzky; Derek A Willoughby; Toby Lawrence
Journal:  FASEB J       Date:  2003-10-16       Impact factor: 5.191

9.  Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.

Authors:  Mohit Kapoor; Matthew McCann; Shangxi Liu; Kun Huh; Christopher P Denton; David J Abraham; Andrew Leask
Journal:  Arthritis Rheum       Date:  2009-09

10.  Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway.

Authors:  Richard Stratton; Vineeth Rajkumar; Markella Ponticos; Blake Nichols; Xu Shiwen; Carol M Black; David J Abraham; Andrew Leask
Journal:  FASEB J       Date:  2002-10-04       Impact factor: 5.191
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  13 in total

1.  Serum concentrations of cyclooxygenase-2 in patients with systemic sclerosis: association with lower frequency of pulmonary fibrosis.

Authors:  Iman H Bassyouni; Roba M Talaat; Tarek A Salem
Journal:  J Clin Immunol       Date:  2011-10-07       Impact factor: 8.317

2.  Iloprost Affects Macrophage Activation and CCL2 Concentrations in a Microdialysis Model in Rats.

Authors:  Kamel Alkhatib; Tina M Poseno; Alda Diaz Perez; Jeannine M Durdik; Julie A Stenken
Journal:  Pharm Res       Date:  2018-01-05       Impact factor: 4.200

3.  B cell block: is rituximab a new possible treatment for systemic sclerosis?

Authors:  Andrew Leask
Journal:  J Cell Commun Signal       Date:  2010-11-20       Impact factor: 5.782

Review 4.  Role of cyclooxygenase-2 in gastric cancer development and progression.

Authors:  Jian Cheng; Xiao-Ming Fan
Journal:  World J Gastroenterol       Date:  2013-11-14       Impact factor: 5.742

5.  Arachidonate 5-lipoxygenase is essential for biosynthesis of specialized pro-resolving mediators and cardiac repair in heart failure.

Authors:  Ganesh V Halade; Vasundhara Kain; Shahriare Hossain; Vibhu Parcha; Nita A Limdi; Pankaj Arora
Journal:  Am J Physiol Heart Circ Physiol       Date:  2022-08-26       Impact factor: 5.125

6.  Comparative parallel multi-omics analysis during the induction of pluripotent and trophectoderm states.

Authors:  Mohammad Jaber; Ahmed Radwan; Netanel Loyfer; Mufeed Abdeen; Shulamit Sebban; Areej Khatib; Hazar Yassen; Thorsten Kolb; Marc Zapatka; Kirill Makedonski; Aurelie Ernst; Tommy Kaplan; Yosef Buganim
Journal:  Nat Commun       Date:  2022-06-17       Impact factor: 17.694

7.  Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission.

Authors:  Netali Ben-Baruch Morgenstern; Adina Y Ballaban; Ting Wen; Tetsuo Shoda; Julie M Caldwell; Kara Kliewer; Jennifer M Felton; J Pablo Abonia; Vincent A Mukkada; Philip E Putnam; Scott M Bolton; Daniel F Dwyer; Nora A Barrett; Marc E Rothenberg
Journal:  J Allergy Clin Immunol       Date:  2022-03-15       Impact factor: 14.290

8.  mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis.

Authors:  Matthew R McCann; Roxana Monemdjou; Parisa Ghassemi-Kakroodi; Hassan Fahmi; Gemma Perez; Shangxi Liu; Xu Shi-Wen; Sunil K Parapuram; Fumiaki Kojima; Christopher P Denton; David J Abraham; Johanne Martel-Pelletier; Leslie J Crofford; Andrew Leask; Mohit Kapoor
Journal:  Arthritis Res Ther       Date:  2011-01-25       Impact factor: 5.156

9.  Induced Pluripotent Stem Cells Inhibit Bleomycin-Induced Pulmonary Fibrosis in Mice through Suppressing TGF-β1/Smad-Mediated Epithelial to Mesenchymal Transition.

Authors:  Yan Zhou; Zhong He; Yuan Gao; Rui Zheng; Xiaoye Zhang; Li Zhao; Mingqi Tan
Journal:  Front Pharmacol       Date:  2016-11-15       Impact factor: 5.810

10.  Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis.

Authors:  Hongyun Zhao; Yee Chan-Li; Samuel L Collins; Yuan Zhang; Robert W Hallowell; Wayne Mitzner; Maureen R Horton
Journal:  BMC Pulm Med       Date:  2014-04-18       Impact factor: 3.317
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