| Literature DB >> 20529684 |
Stephen A Kolodziej1, Susan L Hockerman, Terri L Boehm, Jeffery N Carroll, Gary A DeCrescenzo, Joseph J McDonald, Debbie A Mischke, Grace E Munie, Theresa R Fletcher, Joseph G Rico, Nathan W Stehle, Craig Swearingen, Daniel P Becker.
Abstract
A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20529684 DOI： 10.1016/j.bmcl.2010.04.130
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823