| Literature DB >> 20529681 |
Mayalen Oxoby1, François Moreau, Lionel Durant, Alexis Denis, Jean-Marie Genevard, Vanida Vongsouthi, Sonia Escaich, Vincent Gerusz.
Abstract
A structure-activity relationship study from a screening hit and structure-based design strategy has led to the identification of bisarylureas as potent inhibitors of Streptococcus agalactiae Stk1. As this target has been directly linked to bacterial virulence, these inhibitors can be considered as a promising step towards antivirulence drugs. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20529681 PMCID： PMC2923816 DOI： 10.1016/j.bmcl.2010.04.150
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823