OBJECTIVE: The importance of adiponectin in coronary heart disease remains to be elucidated. Therefore, the associations between plasma adiponectin levels and i) myocardial infarction and ii) genetic variation within the adiponectin gene were investigated. METHODS: The study included young survivors (age <60 years) of a first myocardial infarction and gender- and age-matched controls (244 pairs). Adiponectin concentrations were analysed by radioimmunoassay. Two polymorphisms, rs266729 and rs1501299, of the adiponectin gene ADIPOQ were genotyped. RESULTS: Adiponectin levels were inversely associated with myocardial infarction [odds ratio (OR) 9.3, 95% confidence interval (CI) 4.7-18.2, for the lowest quartile compared to the highest quartile]. This persisted after adjustment for history of hypertension, HDL cholesterol, smoking and body mass index (BMI) (OR 3.1, 95% CI 1.3-7.6). The rs266729 polymorphism was associated with adiponectin levels. Plasma adiponectin concentrations were lower in individuals with the rare G/G genotype [median 4.3 mg/L, [corrected] interquartile range (IQR) 2.8-6.2] compared to the C/G (median 5.8 mg/L), [corrected] IQR 3.9-8.0; P = 0.035) and C/C genotypes (median 5.5 mg/L, [corrected] IQR 4.0-7.5; P = 0.083). CONCLUSION: Low plasma adiponectin concentrations are associated with myocardial infarction in individuals below the age of 60, and this remains significant after adjustment for history of hypertension, HDL cholesterol, smoking and BMI. In addition, adiponectin levels differ according to rs266729 genotype.
OBJECTIVE: The importance of adiponectin in coronary heart disease remains to be elucidated. Therefore, the associations between plasma adiponectin levels and i) myocardial infarction and ii) genetic variation within the adiponectin gene were investigated. METHODS: The study included young survivors (age <60 years) of a first myocardial infarction and gender- and age-matched controls (244 pairs). Adiponectin concentrations were analysed by radioimmunoassay. Two polymorphisms, rs266729 and rs1501299, of the adiponectin gene ADIPOQ were genotyped. RESULTS:Adiponectin levels were inversely associated with myocardial infarction [odds ratio (OR) 9.3, 95% confidence interval (CI) 4.7-18.2, for the lowest quartile compared to the highest quartile]. This persisted after adjustment for history of hypertension, HDL cholesterol, smoking and body mass index (BMI) (OR 3.1, 95% CI 1.3-7.6). The rs266729 polymorphism was associated with adiponectin levels. Plasma adiponectin concentrations were lower in individuals with the rare G/G genotype [median 4.3 mg/L, [corrected] interquartile range (IQR) 2.8-6.2] compared to the C/G (median 5.8 mg/L), [corrected] IQR 3.9-8.0; P = 0.035) and C/C genotypes (median 5.5 mg/L, [corrected] IQR 4.0-7.5; P = 0.083). CONCLUSION: Low plasma adiponectin concentrations are associated with myocardial infarction in individuals below the age of 60, and this remains significant after adjustment for history of hypertension, HDL cholesterol, smoking and BMI. In addition, adiponectin levels differ according to rs266729 genotype.
Authors: J Bassols; J-M Martínez-Calcerrada; A Prats-Puig; G Carreras-Badosa; S Xargay-Torrent; E Lizarraga-Mollinedo; M Feliu-Alsina; E Riera-Pérez; I Osiniri; F de Zegher; L Ibáñez; A López-Bermejo Journal: Int J Obes (Lond) Date: 2017-09-25 Impact factor: 5.095
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Authors: Jonas Persson; Rona J Strawbridge; Olga McLeod; Karl Gertow; Angela Silveira; Damiano Baldassarre; Natalie Van Zuydam; Sonia Shah; Cristiano Fava; Stefan Gustafsson; Fabrizio Veglia; Bengt Sennblad; Malin Larsson; Maria Sabater-Lleal; Karin Leander; Bruna Gigante; Adam Tabak; Mika Kivimaki; Jussi Kauhanen; Rainer Rauramaa; Andries J Smit; Elmo Mannarino; Philippe Giral; Steve E Humphries; Elena Tremoli; Ulf de Faire; Lars Lind; Erik Ingelsson; Bo Hedblad; Olle Melander; Meena Kumari; Aroon Hingorani; Andrew D Morris; Colin N A Palmer; Pia Lundman; John Öhrvik; Stefan Söderberg; Anders Hamsten Journal: J Am Heart Assoc Date: 2015-08-14 Impact factor: 5.501